Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease

Graves’ disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies show correlations between gut microbiota and GD. The dysbios...

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Autores principales: Liu, Haihua, Liu, Huiying, Liu, Chang, Shang, Mengxue, Wei, Tianfu, Yin, Peiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889015/
https://www.ncbi.nlm.nih.gov/pubmed/35252357
http://dx.doi.org/10.3389/fmolb.2022.841223
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author Liu, Haihua
Liu, Huiying
Liu, Chang
Shang, Mengxue
Wei, Tianfu
Yin, Peiyuan
author_facet Liu, Haihua
Liu, Huiying
Liu, Chang
Shang, Mengxue
Wei, Tianfu
Yin, Peiyuan
author_sort Liu, Haihua
collection PubMed
description Graves’ disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies show correlations between gut microbiota and GD. The dysbiosis of gut microbiota may be the reason for the development of GD by modulating the immune system. Metabolites act as mediators or modulators between gut microbiota and thyroid. The purpose of this review is to summarize the correlations between gut microbiota, microbial metabolites and GD. Challenges in the future study are also discussed. The combination of microbiome and metabolome may provide new insight for the study and put forward the diagnosis, treatment, prevention of GD in the future.
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spelling pubmed-88890152022-03-03 Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease Liu, Haihua Liu, Huiying Liu, Chang Shang, Mengxue Wei, Tianfu Yin, Peiyuan Front Mol Biosci Molecular Biosciences Graves’ disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies show correlations between gut microbiota and GD. The dysbiosis of gut microbiota may be the reason for the development of GD by modulating the immune system. Metabolites act as mediators or modulators between gut microbiota and thyroid. The purpose of this review is to summarize the correlations between gut microbiota, microbial metabolites and GD. Challenges in the future study are also discussed. The combination of microbiome and metabolome may provide new insight for the study and put forward the diagnosis, treatment, prevention of GD in the future. Frontiers Media S.A. 2022-02-16 /pmc/articles/PMC8889015/ /pubmed/35252357 http://dx.doi.org/10.3389/fmolb.2022.841223 Text en Copyright © 2022 Liu, Liu, Liu, Shang, Wei and Yin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Liu, Haihua
Liu, Huiying
Liu, Chang
Shang, Mengxue
Wei, Tianfu
Yin, Peiyuan
Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease
title Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease
title_full Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease
title_fullStr Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease
title_full_unstemmed Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease
title_short Gut Microbiome and the Role of Metabolites in the Study of Graves’ Disease
title_sort gut microbiome and the role of metabolites in the study of graves’ disease
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889015/
https://www.ncbi.nlm.nih.gov/pubmed/35252357
http://dx.doi.org/10.3389/fmolb.2022.841223
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