Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report

The unprecedented growth of the high-throughput next-generation sequencing has facilitated the identification of rare oncogene fusions such as ROS1 for NSCLC. ROS1 rearrangement has been observed in only 2% of cases of NSCLC and has been successfully targeted using various tyrosine kinase inhibitors...

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Detalles Bibliográficos
Autores principales: Batra, Ullas, Nathany, Shrinidhi, Sharma, Mansi, Mattoo, Sakshi, Jose, Joslia T., Mehta, Anurag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889240/
https://www.ncbi.nlm.nih.gov/pubmed/35252896
http://dx.doi.org/10.1016/j.jtocrr.2022.100286
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author Batra, Ullas
Nathany, Shrinidhi
Sharma, Mansi
Mattoo, Sakshi
Jose, Joslia T.
Mehta, Anurag
author_facet Batra, Ullas
Nathany, Shrinidhi
Sharma, Mansi
Mattoo, Sakshi
Jose, Joslia T.
Mehta, Anurag
author_sort Batra, Ullas
collection PubMed
description The unprecedented growth of the high-throughput next-generation sequencing has facilitated the identification of rare oncogene fusions such as ROS1 for NSCLC. ROS1 rearrangement has been observed in only 2% of cases of NSCLC and has been successfully targeted using various tyrosine kinase inhibitors including crizotinib. However, the on-target and off-target mechanisms of the resistance are still vague. Here, we report a case of a patient with ROS1 rearranged NSCLC presenting primary resistance to crizotinib.
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spelling pubmed-88892402022-03-03 Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report Batra, Ullas Nathany, Shrinidhi Sharma, Mansi Mattoo, Sakshi Jose, Joslia T. Mehta, Anurag JTO Clin Res Rep Case Report The unprecedented growth of the high-throughput next-generation sequencing has facilitated the identification of rare oncogene fusions such as ROS1 for NSCLC. ROS1 rearrangement has been observed in only 2% of cases of NSCLC and has been successfully targeted using various tyrosine kinase inhibitors including crizotinib. However, the on-target and off-target mechanisms of the resistance are still vague. Here, we report a case of a patient with ROS1 rearranged NSCLC presenting primary resistance to crizotinib. Elsevier 2022-02-04 /pmc/articles/PMC8889240/ /pubmed/35252896 http://dx.doi.org/10.1016/j.jtocrr.2022.100286 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Batra, Ullas
Nathany, Shrinidhi
Sharma, Mansi
Mattoo, Sakshi
Jose, Joslia T.
Mehta, Anurag
Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report
title Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report
title_full Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report
title_fullStr Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report
title_full_unstemmed Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report
title_short Unusual Resistance Mechanisms in a Case of ROS1-Rearranged NSCLC: A Case Report
title_sort unusual resistance mechanisms in a case of ros1-rearranged nsclc: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889240/
https://www.ncbi.nlm.nih.gov/pubmed/35252896
http://dx.doi.org/10.1016/j.jtocrr.2022.100286
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