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N-acetylglucosaminyltransferase-V requires a specific noncatalytic luminal domain for its activity toward glycoprotein substrates

N-acetylglucosaminyltransferase-V (GnT-V or MGAT5) catalyzes the formation of an N-glycan β1,6-GlcNAc branch on selective target proteins in the Golgi apparatus and is involved in cancer malignancy and autoimmune disease etiology. Several three-dimensional structures of GnT-V were recently solved, a...

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Detalles Bibliográficos
Autores principales:	Osuka, Reina F., Hirata, Tetsuya, Nagae, Masamichi, Nakano, Miyako, Shibata, Hiroyuki, Okamoto, Ryo, Kizuka, Yasuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889256/ https://www.ncbi.nlm.nih.gov/pubmed/35104505 http://dx.doi.org/10.1016/j.jbc.2022.101666

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