Cargando…

Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture

The emergence of brain organoids as a model system has been a tremendously exciting development in the field of neuroscience. Brain organoids are a gateway to exploring the intricacies of human-specific neurogenesis that have so far eluded the neuroscience community. Regardless, current culture meth...

Descripción completa

Detalles Bibliográficos
Autores principales: Jang, Hyunsoo, Kim, Seo Hyun, Koh, Youmin, Yoon, Ki-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889333/
https://www.ncbi.nlm.nih.gov/pubmed/35220291
http://dx.doi.org/10.15283/ijsc22004
_version_ 1784661373344546816
author Jang, Hyunsoo
Kim, Seo Hyun
Koh, Youmin
Yoon, Ki-Jun
author_facet Jang, Hyunsoo
Kim, Seo Hyun
Koh, Youmin
Yoon, Ki-Jun
author_sort Jang, Hyunsoo
collection PubMed
description The emergence of brain organoids as a model system has been a tremendously exciting development in the field of neuroscience. Brain organoids are a gateway to exploring the intricacies of human-specific neurogenesis that have so far eluded the neuroscience community. Regardless, current culture methods have a long way to go in terms of accuracy and reproducibility. To perfectly mimic the human brain, we need to recapitulate the complex in vivo context of the human fetal brain and achieve mature neural circuitry with an intact cytoarchitecture. In this review, we explore the major challenges facing the current brain organoid systems, potential technical breakthroughs to advance brain organoid techniques up to levels similar to an in vivo human developing brain, and the future prospects of this technology.
format Online
Article
Text
id pubmed-8889333
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Korean Society for Stem Cell Research
record_format MEDLINE/PubMed
spelling pubmed-88893332022-03-10 Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture Jang, Hyunsoo Kim, Seo Hyun Koh, Youmin Yoon, Ki-Jun Int J Stem Cells Review Article The emergence of brain organoids as a model system has been a tremendously exciting development in the field of neuroscience. Brain organoids are a gateway to exploring the intricacies of human-specific neurogenesis that have so far eluded the neuroscience community. Regardless, current culture methods have a long way to go in terms of accuracy and reproducibility. To perfectly mimic the human brain, we need to recapitulate the complex in vivo context of the human fetal brain and achieve mature neural circuitry with an intact cytoarchitecture. In this review, we explore the major challenges facing the current brain organoid systems, potential technical breakthroughs to advance brain organoid techniques up to levels similar to an in vivo human developing brain, and the future prospects of this technology. Korean Society for Stem Cell Research 2022-02-28 /pmc/articles/PMC8889333/ /pubmed/35220291 http://dx.doi.org/10.15283/ijsc22004 Text en Copyright © 2022 by the Korean Society for Stem Cell Research https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jang, Hyunsoo
Kim, Seo Hyun
Koh, Youmin
Yoon, Ki-Jun
Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture
title Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture
title_full Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture
title_fullStr Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture
title_full_unstemmed Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture
title_short Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture
title_sort engineering brain organoids: toward mature neural circuitry with an intact cytoarchitecture
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889333/
https://www.ncbi.nlm.nih.gov/pubmed/35220291
http://dx.doi.org/10.15283/ijsc22004
work_keys_str_mv AT janghyunsoo engineeringbrainorganoidstowardmatureneuralcircuitrywithanintactcytoarchitecture
AT kimseohyun engineeringbrainorganoidstowardmatureneuralcircuitrywithanintactcytoarchitecture
AT kohyoumin engineeringbrainorganoidstowardmatureneuralcircuitrywithanintactcytoarchitecture
AT yoonkijun engineeringbrainorganoidstowardmatureneuralcircuitrywithanintactcytoarchitecture