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A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells

Natural killer (NK) cells are cytotoxic innate lymphoid cells that are emerging as a cellular immunotherapy for various malignancies. NK cells are particularly dependent on interleukin (IL)-15 for their survival, proliferation, and cytotoxic function. NK cells differentiate into memory-like cells wi...

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Detalles Bibliográficos
Autores principales:	Cubitt, Celia C., McClain, Ethan, Becker-Hapak, Michelle, Foltz, Jennifer A., Wong, Pamela, Wagner, Julia A., Neal, Carly C., Marin, Nancy D., Marsala, Lynne, Foster, Mark, Schappe, Timothy, Soon-Shiong, Patrick, Lee, John, Berrien-Elliott, Melissa M., Fehniger, Todd A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889352/ https://www.ncbi.nlm.nih.gov/pubmed/35284622 http://dx.doi.org/10.1016/j.omto.2022.02.009

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