Fenofibrate reduces cisplatin-induced apoptosis by inhibiting the p53/Puma/Caspase-9 pathway and the MAPK/Caspase-8 pathway rather than by promoting autophagy in murine renal proximal tubular cells

The main lesion of cisplatin nephrotoxicity is damage to proximal tubular cells due to increased apoptosis via the mitochondrial and death receptor pathways, which may be alleviated by appropriate promotion of autophagy. Fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-α) activa...

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Detalles Bibliográficos
Autores principales: Kimura, Hideki, Kamiyama, Kazuko, Imamoto, Toru, Takeda, Izumi, Masunaga, Shinya, Kobayashi, Mamiko, Mikami, Daisuke, Takahashi, Naoki, Kasuno, Kenji, Sugaya, Takeshi, Iwano, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889369/
https://www.ncbi.nlm.nih.gov/pubmed/35252595
http://dx.doi.org/10.1016/j.bbrep.2022.101237

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