Combinatorial Polycation Synthesis and Causal Machine Learning Reveal Divergent Polymer Design Rules for Effective pDNA and Ribonucleoprotein Delivery

[Image: see text] The development of polymers that can replace engineered viral vectors in clinical gene therapy has proven elusive despite the vast portfolios of multifunctional polymers generated by advances in polymer synthesis. Functional delivery of payloads such as plasmids (pDNA) and ribonucl...

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Detalles Bibliográficos
Autores principales: Kumar, Ramya, Le, Ngoc, Oviedo, Felipe, Brown, Mary E., Reineke, Theresa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889556/
https://www.ncbi.nlm.nih.gov/pubmed/35252992
http://dx.doi.org/10.1021/jacsau.1c00467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889556/
https://www.ncbi.nlm.nih.gov/pubmed/35252992
http://dx.doi.org/10.1021/jacsau.1c00467

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