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Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries
BACKGROUND: To compare the prevalence of healthy aging among adults age 70 and older from 5 European countries recruited for the DO-HEALTH clinical trial. Participants were selected for absence of prior major health events. METHODS: Cross-sectional analysis of DO-HEALTH baseline data. All 2,157 part...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889763/ https://www.ncbi.nlm.nih.gov/pubmed/35236290 http://dx.doi.org/10.1186/s12877-022-02755-8 |
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author | Schietzel, Simeon Chocano-Bedoya, Patricia O. Sadlon, Angelique Gagesch, Michael Willett, Walter C. Orav, Endel J. Kressig, Reto W. Vellas, Bruno Rizzoli, René da Silva, José A. P. Blauth, Michael Kanis, John A. Egli, Andreas Bischoff-Ferrari, Heike A. |
author_facet | Schietzel, Simeon Chocano-Bedoya, Patricia O. Sadlon, Angelique Gagesch, Michael Willett, Walter C. Orav, Endel J. Kressig, Reto W. Vellas, Bruno Rizzoli, René da Silva, José A. P. Blauth, Michael Kanis, John A. Egli, Andreas Bischoff-Ferrari, Heike A. |
author_sort | Schietzel, Simeon |
collection | PubMed |
description | BACKGROUND: To compare the prevalence of healthy aging among adults age 70 and older from 5 European countries recruited for the DO-HEALTH clinical trial. Participants were selected for absence of prior major health events. METHODS: Cross-sectional analysis of DO-HEALTH baseline data. All 2,157 participants (mean age 74.9, SD 4.4; 61.7% women) were included and 2,123 had data for all domains of the healthy aging status (HA) definition. HA was assessed based on the Nurses` Health Study (NHS) definition requiring four domains: no major chronic diseases, no disabilities, no cognitive impairment (Montreal Cognitive Assessment, MoCA ≥25), no mental health limitation (GDS-5 <2, and no diagnosis of depression). Association between HA and age, BMI, gender, and physical function (sit-to-stand, gait speed, grip strength) was assessed by multivariate logistic regression analyses adjusting for center. RESULTS: Overall, 41.8% of DO-HEALTH participants were healthy agers with significant variability by country: Austria (Innsbruck) 58.3%, Switzerland (Zurich, Basel, Geneva) 51.2%, Germany (Berlin) 37.6%, France (Toulouse) 36.7% and Portugal (Coimbra) 8.8% (p <0.0001). Differences in prevalence by country persisted after adjustment for age. In the multivariate model, younger age (OR = 0.95, 95% CI 0.93 to 0.98), female gender (OR = 1.36, 95% CI 1.03 to 1.81), lower BMI (OR = 0.94, 95% CI 0.91 to 0.96), faster gait speed (OR = 4.70, 95% CI 2.68 to 8.25) and faster performance in sit-to-stand test (OR = 0.90, 95% CI 0.87 to 0.93) were independently and significantly associated with HA. CONCLUSIONS: Despite the same inclusion and exclusion criteria preselecting relatively healthy adults age 70 years and older, HA prevalence in DO-HEALTH varied significantly between countries and was highest in participants from Austria and Switzerland, lowest in participants from Portugal. Independent of country, younger age, female gender, lower BMI and better physical function were associated with HA. TRIAL REGISTRATION: DO-HEALTH was registered under the protocol NCT01745263 at the International Trials Registry (clinicaltrials.gov), and under the protocol number 2012–001249-41 at the Registration at the European Community Clinical Trial System (EudraCT). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-02755-8. |
format | Online Article Text |
id | pubmed-8889763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-88897632022-03-09 Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries Schietzel, Simeon Chocano-Bedoya, Patricia O. Sadlon, Angelique Gagesch, Michael Willett, Walter C. Orav, Endel J. Kressig, Reto W. Vellas, Bruno Rizzoli, René da Silva, José A. P. Blauth, Michael Kanis, John A. Egli, Andreas Bischoff-Ferrari, Heike A. BMC Geriatr Research BACKGROUND: To compare the prevalence of healthy aging among adults age 70 and older from 5 European countries recruited for the DO-HEALTH clinical trial. Participants were selected for absence of prior major health events. METHODS: Cross-sectional analysis of DO-HEALTH baseline data. All 2,157 participants (mean age 74.9, SD 4.4; 61.7% women) were included and 2,123 had data for all domains of the healthy aging status (HA) definition. HA was assessed based on the Nurses` Health Study (NHS) definition requiring four domains: no major chronic diseases, no disabilities, no cognitive impairment (Montreal Cognitive Assessment, MoCA ≥25), no mental health limitation (GDS-5 <2, and no diagnosis of depression). Association between HA and age, BMI, gender, and physical function (sit-to-stand, gait speed, grip strength) was assessed by multivariate logistic regression analyses adjusting for center. RESULTS: Overall, 41.8% of DO-HEALTH participants were healthy agers with significant variability by country: Austria (Innsbruck) 58.3%, Switzerland (Zurich, Basel, Geneva) 51.2%, Germany (Berlin) 37.6%, France (Toulouse) 36.7% and Portugal (Coimbra) 8.8% (p <0.0001). Differences in prevalence by country persisted after adjustment for age. In the multivariate model, younger age (OR = 0.95, 95% CI 0.93 to 0.98), female gender (OR = 1.36, 95% CI 1.03 to 1.81), lower BMI (OR = 0.94, 95% CI 0.91 to 0.96), faster gait speed (OR = 4.70, 95% CI 2.68 to 8.25) and faster performance in sit-to-stand test (OR = 0.90, 95% CI 0.87 to 0.93) were independently and significantly associated with HA. CONCLUSIONS: Despite the same inclusion and exclusion criteria preselecting relatively healthy adults age 70 years and older, HA prevalence in DO-HEALTH varied significantly between countries and was highest in participants from Austria and Switzerland, lowest in participants from Portugal. Independent of country, younger age, female gender, lower BMI and better physical function were associated with HA. TRIAL REGISTRATION: DO-HEALTH was registered under the protocol NCT01745263 at the International Trials Registry (clinicaltrials.gov), and under the protocol number 2012–001249-41 at the Registration at the European Community Clinical Trial System (EudraCT). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-02755-8. BioMed Central 2022-03-02 /pmc/articles/PMC8889763/ /pubmed/35236290 http://dx.doi.org/10.1186/s12877-022-02755-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Schietzel, Simeon Chocano-Bedoya, Patricia O. Sadlon, Angelique Gagesch, Michael Willett, Walter C. Orav, Endel J. Kressig, Reto W. Vellas, Bruno Rizzoli, René da Silva, José A. P. Blauth, Michael Kanis, John A. Egli, Andreas Bischoff-Ferrari, Heike A. Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries |
title | Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries |
title_full | Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries |
title_fullStr | Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries |
title_full_unstemmed | Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries |
title_short | Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries |
title_sort | prevalence of healthy aging among community dwelling adults age 70 and older from five european countries |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889763/ https://www.ncbi.nlm.nih.gov/pubmed/35236290 http://dx.doi.org/10.1186/s12877-022-02755-8 |
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