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Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection
Symptoms following acute COVID-19 infection are common, but their relationship to initial COVID-19 severity is unclear. We hypothesize that residual symptoms are related to disease severity, and severe acute COVID-19 infection is more likely to cause residual pulmonary damage. This study aims to eva...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889872/ https://www.ncbi.nlm.nih.gov/pubmed/35235130 http://dx.doi.org/10.1007/s11739-022-02950-w |
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author | Darawshy, Fares Abu Rmeileh, Ayman Kuint, Rottem Padawer, Dan Karim, Khalil Fridlender, Zvi Laxer, Uri Goychman Cohen, Polina Berkman, Neville |
author_facet | Darawshy, Fares Abu Rmeileh, Ayman Kuint, Rottem Padawer, Dan Karim, Khalil Fridlender, Zvi Laxer, Uri Goychman Cohen, Polina Berkman, Neville |
author_sort | Darawshy, Fares |
collection | PubMed |
description | Symptoms following acute COVID-19 infection are common, but their relationship to initial COVID-19 severity is unclear. We hypothesize that residual symptoms are related to disease severity, and severe acute COVID-19 infection is more likely to cause residual pulmonary damage. This study aims to evaluate symptoms, lung function, and abnormal imaging within 3 months following COVID-19 infection, and to determine whether they are related to initial disease severity. A cross-sectional study was carried out at a designated post-COVID clinic in Hadassah Medical Center, Jerusalem, Israel. Patients with PCR-confirmed SARS-CoV-2 infection were evaluated within 12 weeks following infection and included both admitted and non-admitted subjects. All study participants underwent assessment of symptoms, quality of life (SGRQ), pulmonary function tests, and imaging. A total of 208 patients (age 49.3 ± 16 years) were included in the study. Initial disease severity was mild in 86, moderate in 49, and severe in 73 patients. At the time of follow-up, there were no differences in frequency of residual symptoms or in SGRQ score between groups. Patients with severe COVID-19 were more likely to have residual dyspnea (p = 0.04), lower oxygen saturation (p < 0.01), lower FVC and TLC (p < 0.001, p = 0.03 respectively), abnormal CXR (p < 0.01), and abnormal CT scan (p < 0.01) compared to other groups.Frequency of symptoms and impairment of quality of life at 12 week follow-up are common and are not related to severity of initial COVID-19 disease. In contrast, reduced lung function and abnormal pulmonary imaging are more common in patients with more severe acute COVID-19 infection. |
format | Online Article Text |
id | pubmed-8889872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88898722022-03-02 Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection Darawshy, Fares Abu Rmeileh, Ayman Kuint, Rottem Padawer, Dan Karim, Khalil Fridlender, Zvi Laxer, Uri Goychman Cohen, Polina Berkman, Neville Intern Emerg Med EM - Original Symptoms following acute COVID-19 infection are common, but their relationship to initial COVID-19 severity is unclear. We hypothesize that residual symptoms are related to disease severity, and severe acute COVID-19 infection is more likely to cause residual pulmonary damage. This study aims to evaluate symptoms, lung function, and abnormal imaging within 3 months following COVID-19 infection, and to determine whether they are related to initial disease severity. A cross-sectional study was carried out at a designated post-COVID clinic in Hadassah Medical Center, Jerusalem, Israel. Patients with PCR-confirmed SARS-CoV-2 infection were evaluated within 12 weeks following infection and included both admitted and non-admitted subjects. All study participants underwent assessment of symptoms, quality of life (SGRQ), pulmonary function tests, and imaging. A total of 208 patients (age 49.3 ± 16 years) were included in the study. Initial disease severity was mild in 86, moderate in 49, and severe in 73 patients. At the time of follow-up, there were no differences in frequency of residual symptoms or in SGRQ score between groups. Patients with severe COVID-19 were more likely to have residual dyspnea (p = 0.04), lower oxygen saturation (p < 0.01), lower FVC and TLC (p < 0.001, p = 0.03 respectively), abnormal CXR (p < 0.01), and abnormal CT scan (p < 0.01) compared to other groups.Frequency of symptoms and impairment of quality of life at 12 week follow-up are common and are not related to severity of initial COVID-19 disease. In contrast, reduced lung function and abnormal pulmonary imaging are more common in patients with more severe acute COVID-19 infection. Springer International Publishing 2022-03-02 2022 /pmc/articles/PMC8889872/ /pubmed/35235130 http://dx.doi.org/10.1007/s11739-022-02950-w Text en © The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI) 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | EM - Original Darawshy, Fares Abu Rmeileh, Ayman Kuint, Rottem Padawer, Dan Karim, Khalil Fridlender, Zvi Laxer, Uri Goychman Cohen, Polina Berkman, Neville Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection |
title | Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection |
title_full | Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection |
title_fullStr | Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection |
title_full_unstemmed | Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection |
title_short | Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection |
title_sort | residual symptoms, lung function, and imaging findings in patients recovering from sars-cov-2 infection |
topic | EM - Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889872/ https://www.ncbi.nlm.nih.gov/pubmed/35235130 http://dx.doi.org/10.1007/s11739-022-02950-w |
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