Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers

Effective inactivation of the HER2-HER3 tumor driver has remained elusive because of the challenging attributes of the pseudokinase HER3. We report a structure-function study of constitutive HER2-HER3 signaling to identify opportunities for targeting. The allosteric activation of the HER2 kinase dom...

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Detalles Bibliográficos
Autores principales: Campbell, Marcia R., Ruiz-Saenz, Ana, Peterson, Elliott, Agnew, Christopher, Ayaz, Pelin, Garfinkle, Sam, Littlefield, Peter, Steri, Veronica, Oeffinger, Julie, Sampang, Maryjo, Shan, Yibing, Shaw, David E., Jura, Natalia, Moasser, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889928/
https://www.ncbi.nlm.nih.gov/pubmed/35108525
http://dx.doi.org/10.1016/j.celrep.2021.110291

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