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Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy

OBJECTIVES: To evaluate the association of obstructive sleep apnea (OSA) with high-sensitivity C-reactive protein (CRP) and fibrinogen levels and to assess the effect of short-term therapy using continuous positive airway pressure (CPAP). MATERIAL AND METHODS: A prospective, open-label, controlled t...

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Autores principales: Al-Mughales, Jamil, Wali, Siraj Omar, Manzar, Md. Dilshad, Alhejaili, Faris, Gozal, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brazilian Association of Sleep and Latin American Federation of Sleep 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889979/
https://www.ncbi.nlm.nih.gov/pubmed/35273744
http://dx.doi.org/10.5935/1984-0063.20200117
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author Al-Mughales, Jamil
Wali, Siraj Omar
Manzar, Md. Dilshad
Alhejaili, Faris
Gozal, David
author_facet Al-Mughales, Jamil
Wali, Siraj Omar
Manzar, Md. Dilshad
Alhejaili, Faris
Gozal, David
author_sort Al-Mughales, Jamil
collection PubMed
description OBJECTIVES: To evaluate the association of obstructive sleep apnea (OSA) with high-sensitivity C-reactive protein (CRP) and fibrinogen levels and to assess the effect of short-term therapy using continuous positive airway pressure (CPAP). MATERIAL AND METHODS: A prospective, open-label, controlled trial was conducted among clinically referred patients at risk for OSA undergoing diagnostic polysomnography (PSG). After PSG, the patients were divided into 3 groups: OSA treatment group (TG) (n=21), untreated OSA group (UOG) (n=19), and non-OSA healthy control group (HCG) (n=24). CRP and fibrinogen levels were measured at baseline and one month after treatment. Repeated-measures (RM) ANOVA and ANCOVA were used to compare changes in CRP and fibrinogen levels among the three groups by analyzing between-subject and within-subject effects as functions of time and adjusting for significant covariates. RESULTS: At baseline, OSA subjects had significantly higher CRP [t(52.37)=-2.46, p=0.02)] and fibrinogen levels [t(57)=-2.00, p=0.05)] than HCG subjects. No significant differences in CRP levels [(F(2,58)=2.29, p=0.11)] or fibrinogen levels [(F(2, 58)=1.28, p=0.29)] emerged between TG and HCG subjects after adjusting for the pretest levels. CONCLUSION: CPAP therapy for one month does not affect CRP and fibrinogen levels among moderate-to-severe OSA patients. However, OSA is associated with elevated levels of these inflammatory biomarkers.
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spelling pubmed-88899792022-03-09 Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy Al-Mughales, Jamil Wali, Siraj Omar Manzar, Md. Dilshad Alhejaili, Faris Gozal, David Sleep Sci Original Research OBJECTIVES: To evaluate the association of obstructive sleep apnea (OSA) with high-sensitivity C-reactive protein (CRP) and fibrinogen levels and to assess the effect of short-term therapy using continuous positive airway pressure (CPAP). MATERIAL AND METHODS: A prospective, open-label, controlled trial was conducted among clinically referred patients at risk for OSA undergoing diagnostic polysomnography (PSG). After PSG, the patients were divided into 3 groups: OSA treatment group (TG) (n=21), untreated OSA group (UOG) (n=19), and non-OSA healthy control group (HCG) (n=24). CRP and fibrinogen levels were measured at baseline and one month after treatment. Repeated-measures (RM) ANOVA and ANCOVA were used to compare changes in CRP and fibrinogen levels among the three groups by analyzing between-subject and within-subject effects as functions of time and adjusting for significant covariates. RESULTS: At baseline, OSA subjects had significantly higher CRP [t(52.37)=-2.46, p=0.02)] and fibrinogen levels [t(57)=-2.00, p=0.05)] than HCG subjects. No significant differences in CRP levels [(F(2,58)=2.29, p=0.11)] or fibrinogen levels [(F(2, 58)=1.28, p=0.29)] emerged between TG and HCG subjects after adjusting for the pretest levels. CONCLUSION: CPAP therapy for one month does not affect CRP and fibrinogen levels among moderate-to-severe OSA patients. However, OSA is associated with elevated levels of these inflammatory biomarkers. Brazilian Association of Sleep and Latin American Federation of Sleep 2022 /pmc/articles/PMC8889979/ /pubmed/35273744 http://dx.doi.org/10.5935/1984-0063.20200117 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Al-Mughales, Jamil
Wali, Siraj Omar
Manzar, Md. Dilshad
Alhejaili, Faris
Gozal, David
Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy
title Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy
title_full Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy
title_fullStr Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy
title_full_unstemmed Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy
title_short Pro-inflammatory markers in patients with obstructive sleep apnea and the effect of Continuous Positive Airway Pressure therapy
title_sort pro-inflammatory markers in patients with obstructive sleep apnea and the effect of continuous positive airway pressure therapy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889979/
https://www.ncbi.nlm.nih.gov/pubmed/35273744
http://dx.doi.org/10.5935/1984-0063.20200117
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