Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence

Abnormal expression in skeletal muscle of the double homeobox transcription factor DUX4 underlies pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). Though multiple changes are known to be initiated by aberrant DUX4 expression, the downstream events initiated by DUX4 remain incompletely...

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Detalles Bibliográficos
Autores principales: Masteika, Isabel F., Sathya, Anvitha, Homma, Sachiko, Miller, Bess M., Boyce, Frederick M., Miller, Jeffrey Boone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890089/
https://www.ncbi.nlm.nih.gov/pubmed/35191484
http://dx.doi.org/10.1242/bio.059145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890089/
https://www.ncbi.nlm.nih.gov/pubmed/35191484
http://dx.doi.org/10.1242/bio.059145

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