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Cooperativity as quantification and optimization paradigm for nuclear receptor modulators

Nuclear Receptors (NRs) are highly relevant drug targets, for which small molecule modulation goes beyond a simple ligand/receptor interaction. NR–ligands modulate Protein–Protein Interactions (PPIs) with coregulator proteins. Here we bring forward a cooperativity mechanism for small molecule modula...

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Detalles Bibliográficos
Autores principales:	de Vink, Pim J., Koops, Auke A., D'Arrigo, Giulia, Cruciani, Gabriele, Spyrakis, Francesca, Brunsveld, Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890100/ https://www.ncbi.nlm.nih.gov/pubmed/35340861 http://dx.doi.org/10.1039/d1sc06426f

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