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A novel wireless implant for central venous pressure measurement: First animal experience

BACKGROUND/OBJECTIVE: Central venous pressure (CVP) serves as a surrogate for right atrial pressure, and thus could potentially predict a wider range of heart failure conditions. The purpose of this work is to assess CVP, through an implantable sensor incorporated with a novel anchor design, in the...

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Autores principales: Manavi, Tejaswini, Vazquez, Patricia, O’Grady, Helen, Martina, Jerson, Rose, Michael, Nielsen, Douglas, Fitzpatrick, David, Forouzan, Omid, Nagy, Michael, Sharif, Faisal, Zafar, Haroon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890339/
https://www.ncbi.nlm.nih.gov/pubmed/35265885
http://dx.doi.org/10.1016/j.cvdhj.2020.10.004
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author Manavi, Tejaswini
Vazquez, Patricia
O’Grady, Helen
Martina, Jerson
Rose, Michael
Nielsen, Douglas
Fitzpatrick, David
Forouzan, Omid
Nagy, Michael
Sharif, Faisal
Zafar, Haroon
author_facet Manavi, Tejaswini
Vazquez, Patricia
O’Grady, Helen
Martina, Jerson
Rose, Michael
Nielsen, Douglas
Fitzpatrick, David
Forouzan, Omid
Nagy, Michael
Sharif, Faisal
Zafar, Haroon
author_sort Manavi, Tejaswini
collection PubMed
description BACKGROUND/OBJECTIVE: Central venous pressure (CVP) serves as a surrogate for right atrial pressure, and thus could potentially predict a wider range of heart failure conditions. The purpose of this work is to assess CVP, through an implantable sensor incorporated with a novel anchor design, in the inferior and superior vena cava of an animal model. METHODS: Two animals (Dorset sheep) were implanted with sensors at 3 different locations: inferior vena cava (IVC), superior vena cava (SVC), and pulmonary artery (PA). Two sensors with distinct anchor designs considering anatomical requirements were used. A standard PA sensor (trade name Cordella) was deployed in the PA and SVC, whereas a sensor with a modified cylindrical anchor with various struts was designed to reside in the IVC. Each implant was calibrated against a Millar catheter reference sensor. The ability of the central venous sensors to detect changes in pressure was evaluated by modifying the fluid volume of the animal. RESULTS: The sensors implanted in both sheep were successful, which provided an opportunity to understand the relationship between PA and CVP via simultaneous readings. The mapping and implantation in the IVC took less than 15 minutes. Multiple readings were taken at each implant location using a hand-held reader device under various conditions. CVP recorded in the IVC (6.49 mm Hg) and SVC (6.14 mm Hg) were nearly the same. PA pressure (13–14 mm Hg) measured was higher than CVP, as expected. The SVC waveforms showed clear beats and respiration. Respiration could be seen in the IVC waveforms, but not all beats were easily distinguishable. Both SVC and IVC readings showed increases in pressure (3.7 and 2.7 mm Hg for SVC and IVC, respectively) after fluid overload was induced via extra saline administration. CONCLUSION: In this work, the feasibility of measuring CVP noninvasively was demonstrated. The established ability of wireless PA pressure sensors to enable prevention of decompensation events weeks ahead can now be explored using central venous versions of such sensors.
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spelling pubmed-88903392022-03-08 A novel wireless implant for central venous pressure measurement: First animal experience Manavi, Tejaswini Vazquez, Patricia O’Grady, Helen Martina, Jerson Rose, Michael Nielsen, Douglas Fitzpatrick, David Forouzan, Omid Nagy, Michael Sharif, Faisal Zafar, Haroon Cardiovasc Digit Health J Experimental BACKGROUND/OBJECTIVE: Central venous pressure (CVP) serves as a surrogate for right atrial pressure, and thus could potentially predict a wider range of heart failure conditions. The purpose of this work is to assess CVP, through an implantable sensor incorporated with a novel anchor design, in the inferior and superior vena cava of an animal model. METHODS: Two animals (Dorset sheep) were implanted with sensors at 3 different locations: inferior vena cava (IVC), superior vena cava (SVC), and pulmonary artery (PA). Two sensors with distinct anchor designs considering anatomical requirements were used. A standard PA sensor (trade name Cordella) was deployed in the PA and SVC, whereas a sensor with a modified cylindrical anchor with various struts was designed to reside in the IVC. Each implant was calibrated against a Millar catheter reference sensor. The ability of the central venous sensors to detect changes in pressure was evaluated by modifying the fluid volume of the animal. RESULTS: The sensors implanted in both sheep were successful, which provided an opportunity to understand the relationship between PA and CVP via simultaneous readings. The mapping and implantation in the IVC took less than 15 minutes. Multiple readings were taken at each implant location using a hand-held reader device under various conditions. CVP recorded in the IVC (6.49 mm Hg) and SVC (6.14 mm Hg) were nearly the same. PA pressure (13–14 mm Hg) measured was higher than CVP, as expected. The SVC waveforms showed clear beats and respiration. Respiration could be seen in the IVC waveforms, but not all beats were easily distinguishable. Both SVC and IVC readings showed increases in pressure (3.7 and 2.7 mm Hg for SVC and IVC, respectively) after fluid overload was induced via extra saline administration. CONCLUSION: In this work, the feasibility of measuring CVP noninvasively was demonstrated. The established ability of wireless PA pressure sensors to enable prevention of decompensation events weeks ahead can now be explored using central venous versions of such sensors. Elsevier 2020-10-29 /pmc/articles/PMC8890339/ /pubmed/35265885 http://dx.doi.org/10.1016/j.cvdhj.2020.10.004 Text en © 2020 Heart Rhythm Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Experimental
Manavi, Tejaswini
Vazquez, Patricia
O’Grady, Helen
Martina, Jerson
Rose, Michael
Nielsen, Douglas
Fitzpatrick, David
Forouzan, Omid
Nagy, Michael
Sharif, Faisal
Zafar, Haroon
A novel wireless implant for central venous pressure measurement: First animal experience
title A novel wireless implant for central venous pressure measurement: First animal experience
title_full A novel wireless implant for central venous pressure measurement: First animal experience
title_fullStr A novel wireless implant for central venous pressure measurement: First animal experience
title_full_unstemmed A novel wireless implant for central venous pressure measurement: First animal experience
title_short A novel wireless implant for central venous pressure measurement: First animal experience
title_sort novel wireless implant for central venous pressure measurement: first animal experience
topic Experimental
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890339/
https://www.ncbi.nlm.nih.gov/pubmed/35265885
http://dx.doi.org/10.1016/j.cvdhj.2020.10.004
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