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Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis

Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and further distant metastasis. Previous studies have documented the important roles of gut microbiota-host interactions in...

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Autores principales: Zhang, Ying, Zhang, Lu, Zheng, Sheng, Li, Mengjie, Xu, Chaochao, Jia, Dingjiacheng, Qi, Yadong, Hou, Tongyao, Wang, Lan, Wang, Boya, Li, Aiqing, Chen, Shujie, Si, Jianmin, Zhuo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890384/
https://www.ncbi.nlm.nih.gov/pubmed/35220887
http://dx.doi.org/10.1080/19490976.2022.2038852
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author Zhang, Ying
Zhang, Lu
Zheng, Sheng
Li, Mengjie
Xu, Chaochao
Jia, Dingjiacheng
Qi, Yadong
Hou, Tongyao
Wang, Lan
Wang, Boya
Li, Aiqing
Chen, Shujie
Si, Jianmin
Zhuo, Wei
author_facet Zhang, Ying
Zhang, Lu
Zheng, Sheng
Li, Mengjie
Xu, Chaochao
Jia, Dingjiacheng
Qi, Yadong
Hou, Tongyao
Wang, Lan
Wang, Boya
Li, Aiqing
Chen, Shujie
Si, Jianmin
Zhuo, Wei
author_sort Zhang, Ying
collection PubMed
description Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and further distant metastasis. Previous studies have documented the important roles of gut microbiota-host interactions in the CRC malignancy, and Fusobacterium nucleatum (F. nucleatum) was reported to increase proliferation and invasive activities of CRC cells. However, the potential functions and underlying mechanisms of F. nucleatum in the interactions between CRC cells and endothelial cells and subsequent extravasation remain unclear. Here, we uncovered that F. nucleatum enhanced the adhesion of CRC cells to endothelial cells, promoted extravasation and metastasis by inducing ICAM1 expression. Mechanistically, we identified that F. nucleatum induced a new pattern recognition receptor ALPK1 to activate NF-κB pathway, resulting in the upregulation of ICAM1. Interestingly, the abundance of F. nucleatum in tumor tissues of CRC patients was positively associated with the expression levels of ALPK1 and ICAM1. Moreover, high expression of ALPK1 or ICAM1 was significantly associated with a shorter overall survival time of CRC patients. This study provides a new insight into the role of gut microbiota in engaging into the distant metastasis of CRC cells.
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spelling pubmed-88903842022-03-03 Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis Zhang, Ying Zhang, Lu Zheng, Sheng Li, Mengjie Xu, Chaochao Jia, Dingjiacheng Qi, Yadong Hou, Tongyao Wang, Lan Wang, Boya Li, Aiqing Chen, Shujie Si, Jianmin Zhuo, Wei Gut Microbes Research Paper Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and further distant metastasis. Previous studies have documented the important roles of gut microbiota-host interactions in the CRC malignancy, and Fusobacterium nucleatum (F. nucleatum) was reported to increase proliferation and invasive activities of CRC cells. However, the potential functions and underlying mechanisms of F. nucleatum in the interactions between CRC cells and endothelial cells and subsequent extravasation remain unclear. Here, we uncovered that F. nucleatum enhanced the adhesion of CRC cells to endothelial cells, promoted extravasation and metastasis by inducing ICAM1 expression. Mechanistically, we identified that F. nucleatum induced a new pattern recognition receptor ALPK1 to activate NF-κB pathway, resulting in the upregulation of ICAM1. Interestingly, the abundance of F. nucleatum in tumor tissues of CRC patients was positively associated with the expression levels of ALPK1 and ICAM1. Moreover, high expression of ALPK1 or ICAM1 was significantly associated with a shorter overall survival time of CRC patients. This study provides a new insight into the role of gut microbiota in engaging into the distant metastasis of CRC cells. Taylor & Francis 2022-02-27 /pmc/articles/PMC8890384/ /pubmed/35220887 http://dx.doi.org/10.1080/19490976.2022.2038852 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Zhang, Ying
Zhang, Lu
Zheng, Sheng
Li, Mengjie
Xu, Chaochao
Jia, Dingjiacheng
Qi, Yadong
Hou, Tongyao
Wang, Lan
Wang, Boya
Li, Aiqing
Chen, Shujie
Si, Jianmin
Zhuo, Wei
Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
title Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
title_full Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
title_fullStr Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
title_full_unstemmed Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
title_short Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
title_sort fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing alpk1/nf-κb/icam1 axis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890384/
https://www.ncbi.nlm.nih.gov/pubmed/35220887
http://dx.doi.org/10.1080/19490976.2022.2038852
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