Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma

Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (C...

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Detalles Bibliográficos
Autores principales: Capece, Daria, Franzoso, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890390/
https://www.ncbi.nlm.nih.gov/pubmed/35252551
http://dx.doi.org/10.1080/23723556.2021.2024051
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author Capece, Daria
Franzoso, Guido
author_facet Capece, Daria
Franzoso, Guido
author_sort Capece, Daria
collection PubMed
description Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC.
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spelling pubmed-88903902022-03-03 Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma Capece, Daria Franzoso, Guido Mol Cell Oncol Commentary Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC. Taylor & Francis 2022-01-27 /pmc/articles/PMC8890390/ /pubmed/35252551 http://dx.doi.org/10.1080/23723556.2021.2024051 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Capece, Daria
Franzoso, Guido
Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
title Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
title_full Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
title_fullStr Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
title_full_unstemmed Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
title_short Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
title_sort rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890390/
https://www.ncbi.nlm.nih.gov/pubmed/35252551
http://dx.doi.org/10.1080/23723556.2021.2024051
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