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Targeting coagulation to unlock antitumor immunity?

Besides a number of physical consequences (reduced blood supply, stabilization of circulating tumor microemboli, shielding from the attack of immune cells), the coagulation cascade may specifically regulate antitumor immunity. We recently applied systems biology and genomics to explore the regulatio...

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Detalles Bibliográficos
Autores principales: Galmiche, Antoine, Saidak, Zuzana, Ghiringhelli, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890431/
https://www.ncbi.nlm.nih.gov/pubmed/35251772
http://dx.doi.org/10.1080/2162402X.2022.2045696
Descripción
Sumario:Besides a number of physical consequences (reduced blood supply, stabilization of circulating tumor microemboli, shielding from the attack of immune cells), the coagulation cascade may specifically regulate antitumor immunity. We recently applied systems biology and genomics to explore the regulation of the tumor immune microenvironment by coagulation.