Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021

In brain tissue of three harbor seals of the German North Sea coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific...

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Detalles Bibliográficos
Autores principales: Postel, Alexander, King, Jacqueline, Kaiser, Franziska K., Kennedy, Johanna, Lombardo, Mara Sophie, Reineking, Wencke, de le Roi, Madeleine, Harder, Timm, Pohlmann, Anne, Gerlach, Thomas, Rimmelzwaan, Guus, Rohner, Simon, Striewe, Lotte C., Gross, Stephanie, Schick, Luca A., Klink, Jana C., Kramer, Katharina, Osterhaus, Albert D. M. E., Beer, Martin, Baumgärtner, Wolfgang, Siebert, Ursula, Becher, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Influenza Infections
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890524/
https://www.ncbi.nlm.nih.gov/pubmed/35172704
http://dx.doi.org/10.1080/22221751.2022.2043726
Descripción
Sumario:In brain tissue of three harbor seals of the German North Sea coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627K variants detected in these cases.

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