Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021

In brain tissue of three harbor seals of the German North Sea coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific...

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Autores principales: Postel, Alexander, King, Jacqueline, Kaiser, Franziska K., Kennedy, Johanna, Lombardo, Mara Sophie, Reineking, Wencke, de le Roi, Madeleine, Harder, Timm, Pohlmann, Anne, Gerlach, Thomas, Rimmelzwaan, Guus, Rohner, Simon, Striewe, Lotte C., Gross, Stephanie, Schick, Luca A., Klink, Jana C., Kramer, Katharina, Osterhaus, Albert D. M. E., Beer, Martin, Baumgärtner, Wolfgang, Siebert, Ursula, Becher, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Influenza Infections
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890524/
https://www.ncbi.nlm.nih.gov/pubmed/35172704
http://dx.doi.org/10.1080/22221751.2022.2043726
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author Postel, Alexander
King, Jacqueline
Kaiser, Franziska K.
Kennedy, Johanna
Lombardo, Mara Sophie
Reineking, Wencke
de le Roi, Madeleine
Harder, Timm
Pohlmann, Anne
Gerlach, Thomas
Rimmelzwaan, Guus
Rohner, Simon
Striewe, Lotte C.
Gross, Stephanie
Schick, Luca A.
Klink, Jana C.
Kramer, Katharina
Osterhaus, Albert D. M. E.
Beer, Martin
Baumgärtner, Wolfgang
Siebert, Ursula
Becher, Paul
author_facet Postel, Alexander
King, Jacqueline
Kaiser, Franziska K.
Kennedy, Johanna
Lombardo, Mara Sophie
Reineking, Wencke
de le Roi, Madeleine
Harder, Timm
Pohlmann, Anne
Gerlach, Thomas
Rimmelzwaan, Guus
Rohner, Simon
Striewe, Lotte C.
Gross, Stephanie
Schick, Luca A.
Klink, Jana C.
Kramer, Katharina
Osterhaus, Albert D. M. E.
Beer, Martin
Baumgärtner, Wolfgang
Siebert, Ursula
Becher, Paul
author_sort Postel, Alexander
collection PubMed
description In brain tissue of three harbor seals of the German North Sea coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627K variants detected in these cases.
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spelling pubmed-88905242022-03-03 Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021 Postel, Alexander King, Jacqueline Kaiser, Franziska K. Kennedy, Johanna Lombardo, Mara Sophie Reineking, Wencke de le Roi, Madeleine Harder, Timm Pohlmann, Anne Gerlach, Thomas Rimmelzwaan, Guus Rohner, Simon Striewe, Lotte C. Gross, Stephanie Schick, Luca A. Klink, Jana C. Kramer, Katharina Osterhaus, Albert D. M. E. Beer, Martin Baumgärtner, Wolfgang Siebert, Ursula Becher, Paul Emerg Microbes Infect Influenza Infections In brain tissue of three harbor seals of the German North Sea coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627K variants detected in these cases. Taylor & Francis 2022-03-01 /pmc/articles/PMC8890524/ /pubmed/35172704 http://dx.doi.org/10.1080/22221751.2022.2043726 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Influenza Infections
Postel, Alexander
King, Jacqueline
Kaiser, Franziska K.
Kennedy, Johanna
Lombardo, Mara Sophie
Reineking, Wencke
de le Roi, Madeleine
Harder, Timm
Pohlmann, Anne
Gerlach, Thomas
Rimmelzwaan, Guus
Rohner, Simon
Striewe, Lotte C.
Gross, Stephanie
Schick, Luca A.
Klink, Jana C.
Kramer, Katharina
Osterhaus, Albert D. M. E.
Beer, Martin
Baumgärtner, Wolfgang
Siebert, Ursula
Becher, Paul
Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
title Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
title_full Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
title_fullStr Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
title_full_unstemmed Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
title_short Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
title_sort infections with highly pathogenic avian influenza a virus (hpaiv) h5n8 in harbor seals at the german north sea coast, 2021
topic Influenza Infections
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890524/
https://www.ncbi.nlm.nih.gov/pubmed/35172704
http://dx.doi.org/10.1080/22221751.2022.2043726
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