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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in part via expressing the senescence-associated sec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890612/ https://www.ncbi.nlm.nih.gov/pubmed/35252191 http://dx.doi.org/10.3389/fcell.2022.822816 |
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author | Hu, Li Li, Huiqin Zi, Meiting Li, Wen Liu, Jing Yang, Yang Zhou, Daohong Kong, Qing-Peng Zhang, Yunxia He, Yonghan |
author_facet | Hu, Li Li, Huiqin Zi, Meiting Li, Wen Liu, Jing Yang, Yang Zhou, Daohong Kong, Qing-Peng Zhang, Yunxia He, Yonghan |
author_sort | Hu, Li |
collection | PubMed |
description | Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in part via expressing the senescence-associated secretory phenotype. Elimination of SnCs has the potential to delay aging, treat age-related diseases and extend healthspan. However, once cells becoming senescent, they are more resistant to apoptotic stimuli. Senolytics can selectively eliminate SnCs by targeting the SnC anti-apoptotic pathways (SCAPs). They have been developed as a novel pharmacological strategy to treat various age-related diseases. However, the heterogeneity of the SnCs indicates that SnCs depend on different proteins or pathways for their survival. Thus, a better understanding of the underlying mechanisms for apoptotic resistance of SnCs will provide new molecular targets for the development of cell-specific or broad-spectrum therapeutics to clear SnCs. In this review, we discussed the latest research progresses and challenge in senolytic development, described the significance of regulation of senescence and apoptosis in aging, and systematically summarized the SCAPs involved in the apoptotic resistance in SnCs. |
format | Online Article Text |
id | pubmed-8890612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88906122022-03-03 Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development Hu, Li Li, Huiqin Zi, Meiting Li, Wen Liu, Jing Yang, Yang Zhou, Daohong Kong, Qing-Peng Zhang, Yunxia He, Yonghan Front Cell Dev Biol Cell and Developmental Biology Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in part via expressing the senescence-associated secretory phenotype. Elimination of SnCs has the potential to delay aging, treat age-related diseases and extend healthspan. However, once cells becoming senescent, they are more resistant to apoptotic stimuli. Senolytics can selectively eliminate SnCs by targeting the SnC anti-apoptotic pathways (SCAPs). They have been developed as a novel pharmacological strategy to treat various age-related diseases. However, the heterogeneity of the SnCs indicates that SnCs depend on different proteins or pathways for their survival. Thus, a better understanding of the underlying mechanisms for apoptotic resistance of SnCs will provide new molecular targets for the development of cell-specific or broad-spectrum therapeutics to clear SnCs. In this review, we discussed the latest research progresses and challenge in senolytic development, described the significance of regulation of senescence and apoptosis in aging, and systematically summarized the SCAPs involved in the apoptotic resistance in SnCs. Frontiers Media S.A. 2022-02-16 /pmc/articles/PMC8890612/ /pubmed/35252191 http://dx.doi.org/10.3389/fcell.2022.822816 Text en Copyright © 2022 Hu, Li, Zi, Li, Liu, Yang, Zhou, Kong, Zhang and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Hu, Li Li, Huiqin Zi, Meiting Li, Wen Liu, Jing Yang, Yang Zhou, Daohong Kong, Qing-Peng Zhang, Yunxia He, Yonghan Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development |
title | Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development |
title_full | Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development |
title_fullStr | Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development |
title_full_unstemmed | Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development |
title_short | Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development |
title_sort | why senescent cells are resistant to apoptosis: an insight for senolytic development |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890612/ https://www.ncbi.nlm.nih.gov/pubmed/35252191 http://dx.doi.org/10.3389/fcell.2022.822816 |
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