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First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020

Limited data are available regarding antimicrobial resistance in Neisseria gonorrhoeae strains circulating in WHO Eastern Mediterranean Region (EMR). We investigated the antimicrobial susceptibility/resistance of N. gonorrhoeae isolates to five antimicrobials (ceftriaxone, azithromycin, ciprofloxaci...

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Autores principales: Al-Maslamani, Muna, Elmagboul, Emad Bashier Ibrahim, Puthiyottil, Aslam, Chemaitelly, Hiam, Varghese, Manoj Kizhakkepeedikayil, Al Romaihi, Hamad Eid, Al-Thani, Mohamed H., Al Khal, Abdullatif, Unemo, Magnus, Abu-Raddad, Laith J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890659/
https://www.ncbi.nlm.nih.gov/pubmed/35235608
http://dx.doi.org/10.1371/journal.pone.0264737
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author Al-Maslamani, Muna
Elmagboul, Emad Bashier Ibrahim
Puthiyottil, Aslam
Chemaitelly, Hiam
Varghese, Manoj Kizhakkepeedikayil
Al Romaihi, Hamad Eid
Al-Thani, Mohamed H.
Al Khal, Abdullatif
Unemo, Magnus
Abu-Raddad, Laith J.
author_facet Al-Maslamani, Muna
Elmagboul, Emad Bashier Ibrahim
Puthiyottil, Aslam
Chemaitelly, Hiam
Varghese, Manoj Kizhakkepeedikayil
Al Romaihi, Hamad Eid
Al-Thani, Mohamed H.
Al Khal, Abdullatif
Unemo, Magnus
Abu-Raddad, Laith J.
author_sort Al-Maslamani, Muna
collection PubMed
description Limited data are available regarding antimicrobial resistance in Neisseria gonorrhoeae strains circulating in WHO Eastern Mediterranean Region (EMR). We investigated the antimicrobial susceptibility/resistance of N. gonorrhoeae isolates to five antimicrobials (ceftriaxone, azithromycin, ciprofloxacin, tetracycline, and benzylpenicillin) currently or previously used for gonorrhoea treatment in Qatar, 2017–2020. Minimum inhibitory concentrations (MICs; mg/L) of antimicrobials were determined using Etest on gonococcal isolates collected during January 1, 2017-August 30, 2020 at Hamad Medical Corporation, a national public healthcare provider. During 2017–2020, resistance in isolates from urogenital sites of 433 patients was 64.7% (95% CI: 59.5–69.6%; range: 43.9–78.7%) for ciprofloxacin, 50.7% (95% CI: 45.3–56.1%; range: 41.3–70.4%) for tetracycline, and 30.8% (95% CI: 26.3–35.6%; range: 26.7–35.8%) for benzylpenicillin. Percentage of isolates non-susceptible to azithromycin was 4.1% (95% CI: 2.0–7.4%; range: 2.7–4.8%) and all (100%) isolates were susceptible to ceftriaxone. Two (1.6%) isolates from 2019 and one (2.2%) isolate from 2020 had high-level resistance to azithromycin (MIC≥256 mg/L). Overall, 1.0% (4/418) of isolates had a ceftriaxone MIC of 0.25 mg/L, which is at the ceftriaxone susceptibility breakpoint (MIC≤0.25 mg/L). Treatment with ceftriaxone 250 mg plus azithromycin 1 g can continuously be recommended for gonorrhoea therapy in Qatar. Continued quality-assured gonococcal AMR surveillance is warranted in EMR.
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spelling pubmed-88906592022-03-03 First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020 Al-Maslamani, Muna Elmagboul, Emad Bashier Ibrahim Puthiyottil, Aslam Chemaitelly, Hiam Varghese, Manoj Kizhakkepeedikayil Al Romaihi, Hamad Eid Al-Thani, Mohamed H. Al Khal, Abdullatif Unemo, Magnus Abu-Raddad, Laith J. PLoS One Research Article Limited data are available regarding antimicrobial resistance in Neisseria gonorrhoeae strains circulating in WHO Eastern Mediterranean Region (EMR). We investigated the antimicrobial susceptibility/resistance of N. gonorrhoeae isolates to five antimicrobials (ceftriaxone, azithromycin, ciprofloxacin, tetracycline, and benzylpenicillin) currently or previously used for gonorrhoea treatment in Qatar, 2017–2020. Minimum inhibitory concentrations (MICs; mg/L) of antimicrobials were determined using Etest on gonococcal isolates collected during January 1, 2017-August 30, 2020 at Hamad Medical Corporation, a national public healthcare provider. During 2017–2020, resistance in isolates from urogenital sites of 433 patients was 64.7% (95% CI: 59.5–69.6%; range: 43.9–78.7%) for ciprofloxacin, 50.7% (95% CI: 45.3–56.1%; range: 41.3–70.4%) for tetracycline, and 30.8% (95% CI: 26.3–35.6%; range: 26.7–35.8%) for benzylpenicillin. Percentage of isolates non-susceptible to azithromycin was 4.1% (95% CI: 2.0–7.4%; range: 2.7–4.8%) and all (100%) isolates were susceptible to ceftriaxone. Two (1.6%) isolates from 2019 and one (2.2%) isolate from 2020 had high-level resistance to azithromycin (MIC≥256 mg/L). Overall, 1.0% (4/418) of isolates had a ceftriaxone MIC of 0.25 mg/L, which is at the ceftriaxone susceptibility breakpoint (MIC≤0.25 mg/L). Treatment with ceftriaxone 250 mg plus azithromycin 1 g can continuously be recommended for gonorrhoea therapy in Qatar. Continued quality-assured gonococcal AMR surveillance is warranted in EMR. Public Library of Science 2022-03-02 /pmc/articles/PMC8890659/ /pubmed/35235608 http://dx.doi.org/10.1371/journal.pone.0264737 Text en © 2022 Al-Maslamani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Al-Maslamani, Muna
Elmagboul, Emad Bashier Ibrahim
Puthiyottil, Aslam
Chemaitelly, Hiam
Varghese, Manoj Kizhakkepeedikayil
Al Romaihi, Hamad Eid
Al-Thani, Mohamed H.
Al Khal, Abdullatif
Unemo, Magnus
Abu-Raddad, Laith J.
First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020
title First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020
title_full First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020
title_fullStr First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020
title_full_unstemmed First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020
title_short First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017–2020
title_sort first characterisation of antimicrobial susceptibility and resistance of neisseria gonorrhoeae isolates in qatar, 2017–2020
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890659/
https://www.ncbi.nlm.nih.gov/pubmed/35235608
http://dx.doi.org/10.1371/journal.pone.0264737
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