Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Interleukin-1α (IL-1α) and IL-1β are inflammatory cytokines with important roles in health and disease. They trigger the same receptor and elicit comparable cellular responses but, for poorly understood reasons, are not redundant in vivo. Here, we decoupled IL-1α and IL-1β functions that drive prote...

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Detalles Bibliográficos
Autores principales: Eislmayr, Kevin, Bestehorn, Annika, Morelli, Luisa, Borroni, Martina, Walle, Lieselotte Vande, Lamkanfi, Mohamed, Kovarik, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890706/
https://www.ncbi.nlm.nih.gov/pubmed/35235356
http://dx.doi.org/10.1126/sciadv.abj7293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890706/
https://www.ncbi.nlm.nih.gov/pubmed/35235356
http://dx.doi.org/10.1126/sciadv.abj7293

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