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Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells
Chromosome instability is a critical event in cancer progression. Histone H3 variant CENP-A plays a fundamental role in defining centromere identity, structure, and function but is innately overexpressed in several types of solid cancers. In the cancer background, excess CENP-A is deposited ectopica...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890707/ https://www.ncbi.nlm.nih.gov/pubmed/35235361 http://dx.doi.org/10.1126/sciadv.abl5621 |