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Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling

Mendelian randomization (MR) is a common tool for identifying causal risk factors underlying diseases. Here, we present a method, MR with automated instrument determination (MRAID), for effective MR analysis. MRAID borrows ideas from fine-mapping analysis to model an initial set of candidate single-...

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Detalles Bibliográficos
Autores principales:	Yuan, Zhongshang, Liu, Lu, Guo, Ping, Yan, Ran, Xue, Fuzhong, Zhou, Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890724/ https://www.ncbi.nlm.nih.gov/pubmed/35235357 http://dx.doi.org/10.1126/sciadv.abl5744

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