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Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma

Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lac...

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Autores principales: Sodnom-Ish, Buyanbileg, Eo, Mi Young, Myoung, Hoon, Lee, Jong Ho, Kim, Soung Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Oral and Maxillofacial Surgeons 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890960/
https://www.ncbi.nlm.nih.gov/pubmed/35221302
http://dx.doi.org/10.5125/jkaoms.2022.48.1.3
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author Sodnom-Ish, Buyanbileg
Eo, Mi Young
Myoung, Hoon
Lee, Jong Ho
Kim, Soung Min
author_facet Sodnom-Ish, Buyanbileg
Eo, Mi Young
Myoung, Hoon
Lee, Jong Ho
Kim, Soung Min
author_sort Sodnom-Ish, Buyanbileg
collection PubMed
description Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS.
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spelling pubmed-88909602022-03-10 Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma Sodnom-Ish, Buyanbileg Eo, Mi Young Myoung, Hoon Lee, Jong Ho Kim, Soung Min J Korean Assoc Oral Maxillofac Surg Invited Review Article Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS. The Korean Association of Oral and Maxillofacial Surgeons 2022-02-28 2022-02-28 /pmc/articles/PMC8890960/ /pubmed/35221302 http://dx.doi.org/10.5125/jkaoms.2022.48.1.3 Text en Copyright © 2022 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review Article
Sodnom-Ish, Buyanbileg
Eo, Mi Young
Myoung, Hoon
Lee, Jong Ho
Kim, Soung Min
Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
title Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
title_full Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
title_fullStr Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
title_full_unstemmed Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
title_short Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
title_sort next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
topic Invited Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890960/
https://www.ncbi.nlm.nih.gov/pubmed/35221302
http://dx.doi.org/10.5125/jkaoms.2022.48.1.3
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