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Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Oral and Maxillofacial Surgeons
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890960/ https://www.ncbi.nlm.nih.gov/pubmed/35221302 http://dx.doi.org/10.5125/jkaoms.2022.48.1.3 |
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author | Sodnom-Ish, Buyanbileg Eo, Mi Young Myoung, Hoon Lee, Jong Ho Kim, Soung Min |
author_facet | Sodnom-Ish, Buyanbileg Eo, Mi Young Myoung, Hoon Lee, Jong Ho Kim, Soung Min |
author_sort | Sodnom-Ish, Buyanbileg |
collection | PubMed |
description | Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS. |
format | Online Article Text |
id | pubmed-8890960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Association of Oral and Maxillofacial Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-88909602022-03-10 Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma Sodnom-Ish, Buyanbileg Eo, Mi Young Myoung, Hoon Lee, Jong Ho Kim, Soung Min J Korean Assoc Oral Maxillofac Surg Invited Review Article Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS. The Korean Association of Oral and Maxillofacial Surgeons 2022-02-28 2022-02-28 /pmc/articles/PMC8890960/ /pubmed/35221302 http://dx.doi.org/10.5125/jkaoms.2022.48.1.3 Text en Copyright © 2022 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Article Sodnom-Ish, Buyanbileg Eo, Mi Young Myoung, Hoon Lee, Jong Ho Kim, Soung Min Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma |
title | Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma |
title_full | Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma |
title_fullStr | Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma |
title_full_unstemmed | Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma |
title_short | Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma |
title_sort | next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma |
topic | Invited Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890960/ https://www.ncbi.nlm.nih.gov/pubmed/35221302 http://dx.doi.org/10.5125/jkaoms.2022.48.1.3 |
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