A computational protein design protocol for optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2

The present protocol describes the computational design of the SARS-CoV-2 receptor binding motif (RBD) to identify mutations that can potentially improve binding affinity for the human ACE2 (hACE2) receptor. We focus on four positions located at the interface with the hACE2 receptor in the RBD:hACE2...

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Detalles Bibliográficos
Autores principales: Polydorides, Savvas, Archontis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890969/
https://www.ncbi.nlm.nih.gov/pubmed/35310078
http://dx.doi.org/10.1016/j.xpro.2022.101254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890969/
https://www.ncbi.nlm.nih.gov/pubmed/35310078
http://dx.doi.org/10.1016/j.xpro.2022.101254

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