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A computational protein design protocol for optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2
The present protocol describes the computational design of the SARS-CoV-2 receptor binding motif (RBD) to identify mutations that can potentially improve binding affinity for the human ACE2 (hACE2) receptor. We focus on four positions located at the interface with the hACE2 receptor in the RBD:hACE2...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890969/ https://www.ncbi.nlm.nih.gov/pubmed/35310078 http://dx.doi.org/10.1016/j.xpro.2022.101254 |