The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications(1,2). Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs (3–5)). Although rapid induction of type I IFNs limits virus propagation, a sustain...

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Detalles Bibliográficos
Autores principales: Domizio, Jeremy Di, Gulen, Muhammet F., Saidoune, Fanny, Thacker, Vivek V., Yatim, Ahmad, Sharma, Kunal, Nass, Théo, Guenova, Emmanuella, Schaller, Martin, Conrad, Curdin, Goepfert, Christine, de Leval, Laurence, Garnier, Christophe von, Berezowska, Sabina, Dubois, Anaëlle, Gilliet, Michel, Ablasser, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891013/
https://www.ncbi.nlm.nih.gov/pubmed/35045565
http://dx.doi.org/10.1038/s41586-022-04421-w

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