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Precise druggability of the PTH type 1 receptor

Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because their large orthosteric peptide-binding pocket embedded deep within the transmembrane domain limits the identification and development of non-peptide small molecule ligands. Using the parathyro...

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Detalles Bibliográficos
Autores principales:	Sutkeviciute, Ieva, Lee, Ji Young, White, Alex D., Maria, Christian Santa, Peña, Karina A., Savransky, Sofya, Doruker, Pemra, Li, Hongchun, Lei, Saifei, Kaynak, Burak, Tu, Chialing, Clark, Lisa J., Sanker, Subramaniam, Gardella, Thomas J., Chang, Wenhan, Bahar, Ivet, Vilardaga, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891041/ https://www.ncbi.nlm.nih.gov/pubmed/34949836 http://dx.doi.org/10.1038/s41589-021-00929-w

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