Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models

Myelofibrosis (MF) is the deadliest form of myeloproliferative neoplasm (MPN). The JAK inhibitor Ruxolitinib can reduce constitutional symptoms but it does not substantially improve bone marrow fibrosis. Pim1 expression is significantly elevated in MPN/MF hematopoietic progenitors. Here, we show tha...

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Detalles Bibliográficos
Autores principales: Dutta, Avik, Nath, Dipmoy, Yang, Yue, Le, Bao T., Rahman, Mohammad Ferdous-Ur, Faughnan, Patrick, Wang, Zhenjia, Stuver, Matthew, He, Rongquan, Tan, Wuwei, Hutchison, Robert E., Foulks, Jason M., Warner, Steven L., Zang, Chongzhi, Mohi, Golam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891046/
https://www.ncbi.nlm.nih.gov/pubmed/34741118
http://dx.doi.org/10.1038/s41375-021-01464-2

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