Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway

BRCA1 deficient breast cancers are aggressive and chemoresistant due, in part, to their enrichment of cancer stem cells that can be generated from carcinoma cells by an epithelial-mesenchymal transition (EMT). We previously discovered that BRCA1 deficiency activates EMT in mammary tumorigenesis. How...

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Detalles Bibliográficos
Autores principales: Bai, Feng, Wang, Chuying, Liu, Xiong, Hollern, Daniel, Liu, Shiqin, Fan, Cheng, Liu, Chang, Ren, Sijia, Herschkowitz, Jason I., Zhu, Wei-Guo, Pei, Xin-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891277/
https://www.ncbi.nlm.nih.gov/pubmed/35236825
http://dx.doi.org/10.1038/s41419-022-04646-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891277/
https://www.ncbi.nlm.nih.gov/pubmed/35236825
http://dx.doi.org/10.1038/s41419-022-04646-7

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