Methylation of recombinant mononucleosomes by DNMT3A demonstrates efficient linker DNA methylation and a role of H3K36me3

Recently, the structure of the DNMT3A2/3B3 heterotetramer complex bound to a mononucleosome was reported. Here, we investigate DNA methylation of recombinant unmodified, H3K(C)4me3 and H3K(C)36me3 containing mononucleosomes by DNMT3A2, DNMT3A catalytic domain (DNMT3AC) and the DNMT3AC/3B3C complex....

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Detalles Bibliográficos
Autores principales: Bröhm, Alexander, Schoch, Tabea, Dukatz, Michael, Graf, Nora, Dorscht, Franziska, Mantai, Evelin, Adam, Sabrina, Bashtrykov, Pavel, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891314/
https://www.ncbi.nlm.nih.gov/pubmed/35236925
http://dx.doi.org/10.1038/s42003-022-03119-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891314/
https://www.ncbi.nlm.nih.gov/pubmed/35236925
http://dx.doi.org/10.1038/s42003-022-03119-z

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