ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models

Predisposition to Alzheimer’s disease (AD) may arise from lipid metabolism perturbation, however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA-domain containing protein 3A (ATAD3A), a mitochondrial AAA-ATPase, as a molecular switch that links cholesterol metabolism i...

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Detalles Bibliográficos
Autores principales: Zhao, Yuanyuan, Hu, Di, Wang, Rihua, Sun, Xiaoyan, Ropelewski, Philip, Hubler, Zita, Lundberg, Kathleen, Wang, Quanqiu, Adams, Drew J., Xu, Rong, Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891325/
https://www.ncbi.nlm.nih.gov/pubmed/35236834
http://dx.doi.org/10.1038/s41467-022-28769-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891325/
https://www.ncbi.nlm.nih.gov/pubmed/35236834
http://dx.doi.org/10.1038/s41467-022-28769-9

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