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Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein

OBJECTIVE: Cerebrospinal fluid total protein (CSF-TP) levels in adults with posthemorrhagic hydrocephalus (PHH) are poorly studied. The objective of this study was to explore the characteristics of CSF-TP levels in patients with PHH. METHODS: The clinical data of 156 patients with hemorrhagic brain...

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Detalles Bibliográficos
Autores principales: Wang, Zhiwen, Chen, Yuxin, Zhou, Xinhui, Wang, Changfeng, Chen, Xianjun, Min, Feixiang, Liu, Ruen, Xiang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891476/
https://www.ncbi.nlm.nih.gov/pubmed/35252319
http://dx.doi.org/10.3389/fsurg.2022.692383
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author Wang, Zhiwen
Chen, Yuxin
Zhou, Xinhui
Wang, Changfeng
Chen, Xianjun
Min, Feixiang
Liu, Ruen
Xiang, Hui
author_facet Wang, Zhiwen
Chen, Yuxin
Zhou, Xinhui
Wang, Changfeng
Chen, Xianjun
Min, Feixiang
Liu, Ruen
Xiang, Hui
author_sort Wang, Zhiwen
collection PubMed
description OBJECTIVE: Cerebrospinal fluid total protein (CSF-TP) levels in adults with posthemorrhagic hydrocephalus (PHH) are poorly studied. The objective of this study was to explore the characteristics of CSF-TP levels in patients with PHH. METHODS: The clinical data of 156 patients with hemorrhagic brain disease were retrospectively studied and divided into PHH and NPHH groups. Single-factor and multi-factor analyses were performed, and the key role of CSF-TP was evaluated using linear analysis. RESULTS: Among the 156 patients, 85 (54.5%) had PHH and 34 (21.8%) underwent surgeries. Hypertension (p = 0.017), days [total fever time when body temperature ≥ 38.5°C (p = 0.04)], Glasgow Coma Scale (GCS) score (p < 0.001), and time (from the onset of the disease to the obtainment of CSF-TP after lumbar puncture (p < 0.001) were important factors for PHH. Logistic regression analysis revealed that GCS score < 8 [odds ratio (OR) = 2.943 (1.421–6.097), p = 0.004] and CSF-TP × time ≥ 9,600 [OR = 2.317 (1.108–4.849), p = 0.026] were independent risk factors for PHH. All CSF-TP values were averaged every 2 days. CSF-TP was negatively correlated with time. Linear analysis showed that CSF-TP in the PHH group was higher than that in the NPHH group at the same onset time, and that the duration of detectionin the CSF was longer. CONCLUSION: Cerebrospinal fluid total protein (CSF-TP) × time ≥ 9,600 and GCS score <8 were independent risk factors for PHH. CSF-TP was higher in the PHH group than in the NPHH group.
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spelling pubmed-88914762022-03-04 Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein Wang, Zhiwen Chen, Yuxin Zhou, Xinhui Wang, Changfeng Chen, Xianjun Min, Feixiang Liu, Ruen Xiang, Hui Front Surg Surgery OBJECTIVE: Cerebrospinal fluid total protein (CSF-TP) levels in adults with posthemorrhagic hydrocephalus (PHH) are poorly studied. The objective of this study was to explore the characteristics of CSF-TP levels in patients with PHH. METHODS: The clinical data of 156 patients with hemorrhagic brain disease were retrospectively studied and divided into PHH and NPHH groups. Single-factor and multi-factor analyses were performed, and the key role of CSF-TP was evaluated using linear analysis. RESULTS: Among the 156 patients, 85 (54.5%) had PHH and 34 (21.8%) underwent surgeries. Hypertension (p = 0.017), days [total fever time when body temperature ≥ 38.5°C (p = 0.04)], Glasgow Coma Scale (GCS) score (p < 0.001), and time (from the onset of the disease to the obtainment of CSF-TP after lumbar puncture (p < 0.001) were important factors for PHH. Logistic regression analysis revealed that GCS score < 8 [odds ratio (OR) = 2.943 (1.421–6.097), p = 0.004] and CSF-TP × time ≥ 9,600 [OR = 2.317 (1.108–4.849), p = 0.026] were independent risk factors for PHH. All CSF-TP values were averaged every 2 days. CSF-TP was negatively correlated with time. Linear analysis showed that CSF-TP in the PHH group was higher than that in the NPHH group at the same onset time, and that the duration of detectionin the CSF was longer. CONCLUSION: Cerebrospinal fluid total protein (CSF-TP) × time ≥ 9,600 and GCS score <8 were independent risk factors for PHH. CSF-TP was higher in the PHH group than in the NPHH group. Frontiers Media S.A. 2022-02-17 /pmc/articles/PMC8891476/ /pubmed/35252319 http://dx.doi.org/10.3389/fsurg.2022.692383 Text en Copyright © 2022 Wang, Chen, Zhou, Wang, Chen, Min, Liu and Xiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Wang, Zhiwen
Chen, Yuxin
Zhou, Xinhui
Wang, Changfeng
Chen, Xianjun
Min, Feixiang
Liu, Ruen
Xiang, Hui
Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
title Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
title_full Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
title_fullStr Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
title_full_unstemmed Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
title_short Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
title_sort risk factor of posthemorrhagic hydrocephalus: cerebrospinal fluid total protein
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891476/
https://www.ncbi.nlm.nih.gov/pubmed/35252319
http://dx.doi.org/10.3389/fsurg.2022.692383
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