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Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities

An increasing number of extremely premature infants survive the neonatal period and beyond. Little is known about the maturation of the preterm infant’s metabolome and its relation to the development of morbidities. Using 1H-NMR, we investigated the serum metabolic profile of 87 infants born at a ge...

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Autores principales: Nilsson, Anders K., Tebani, Abdellah, Malmodin, Daniel, Pedersen, Anders, Hellgren, Gunnel, Löfqvist, Chatarina, Hansen-Pupp, Ingrid, Uhlén, Mathias, Hellström, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891494/
https://www.ncbi.nlm.nih.gov/pubmed/35250465
http://dx.doi.org/10.3389/fnins.2022.830884
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author Nilsson, Anders K.
Tebani, Abdellah
Malmodin, Daniel
Pedersen, Anders
Hellgren, Gunnel
Löfqvist, Chatarina
Hansen-Pupp, Ingrid
Uhlén, Mathias
Hellström, Ann
author_facet Nilsson, Anders K.
Tebani, Abdellah
Malmodin, Daniel
Pedersen, Anders
Hellgren, Gunnel
Löfqvist, Chatarina
Hansen-Pupp, Ingrid
Uhlén, Mathias
Hellström, Ann
author_sort Nilsson, Anders K.
collection PubMed
description An increasing number of extremely premature infants survive the neonatal period and beyond. Little is known about the maturation of the preterm infant’s metabolome and its relation to the development of morbidities. Using 1H-NMR, we investigated the serum metabolic profile of 87 infants born at a gestational age (GA) <28 weeks [mean GA (SD) 25.4 (1.4) weeks] in samples longitudinally collected from birth to term equivalent age. The infant metabolome was analyzed in relation to GA, postnatal age, nutrition, and preterm morbidities. At postnatal day 1, low GA correlated with high levels of 3-hydroxyisobutyrate, acetate, acetoacetate, acetone, formate, glucose, and valine. Nearly all quantified metabolites displayed postnatal concentration changes. For example, the two phospholipid-related metabolites myo-inositol and ethanolamine displayed a similar decline from birth over the first weeks of life, irrespectively of GA. The proportion of enteral/parenteral energy intake in the first 28 days significantly correlated with mean levels of 52% of the analyzed metabolites. Low enteral energy intake was associated with high serum levels of 3-hydroxyisobutyrate, creatinine, glucose, glycerol, histidine, lactate, leucine, lysine, methionine, ornithine, phenylalanine, proline, threonine, and uridine. There were also significant correlations between high enteral intake and high serum levels of isoleucine and tyrosine. Retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) outcomes were not significantly associated with metabolite levels in the neonatal period after correcting for multiple testing. In conclusion, the serum metabolome of extremely premature infants changes substantially in the neonatal period, largely driven by the gradual transfer from total parenteral nutrition to full enteral feeding. Further studies are needed to disentangle the intricate relationships between the metabolome, nutritional management, GA, and the development of preterm morbidities.
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spelling pubmed-88914942022-03-04 Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities Nilsson, Anders K. Tebani, Abdellah Malmodin, Daniel Pedersen, Anders Hellgren, Gunnel Löfqvist, Chatarina Hansen-Pupp, Ingrid Uhlén, Mathias Hellström, Ann Front Neurosci Neuroscience An increasing number of extremely premature infants survive the neonatal period and beyond. Little is known about the maturation of the preterm infant’s metabolome and its relation to the development of morbidities. Using 1H-NMR, we investigated the serum metabolic profile of 87 infants born at a gestational age (GA) <28 weeks [mean GA (SD) 25.4 (1.4) weeks] in samples longitudinally collected from birth to term equivalent age. The infant metabolome was analyzed in relation to GA, postnatal age, nutrition, and preterm morbidities. At postnatal day 1, low GA correlated with high levels of 3-hydroxyisobutyrate, acetate, acetoacetate, acetone, formate, glucose, and valine. Nearly all quantified metabolites displayed postnatal concentration changes. For example, the two phospholipid-related metabolites myo-inositol and ethanolamine displayed a similar decline from birth over the first weeks of life, irrespectively of GA. The proportion of enteral/parenteral energy intake in the first 28 days significantly correlated with mean levels of 52% of the analyzed metabolites. Low enteral energy intake was associated with high serum levels of 3-hydroxyisobutyrate, creatinine, glucose, glycerol, histidine, lactate, leucine, lysine, methionine, ornithine, phenylalanine, proline, threonine, and uridine. There were also significant correlations between high enteral intake and high serum levels of isoleucine and tyrosine. Retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) outcomes were not significantly associated with metabolite levels in the neonatal period after correcting for multiple testing. In conclusion, the serum metabolome of extremely premature infants changes substantially in the neonatal period, largely driven by the gradual transfer from total parenteral nutrition to full enteral feeding. Further studies are needed to disentangle the intricate relationships between the metabolome, nutritional management, GA, and the development of preterm morbidities. Frontiers Media S.A. 2022-02-17 /pmc/articles/PMC8891494/ /pubmed/35250465 http://dx.doi.org/10.3389/fnins.2022.830884 Text en Copyright © 2022 Nilsson, Tebani, Malmodin, Pedersen, Hellgren, Löfqvist, Hansen-Pupp, Uhlén and Hellström. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Nilsson, Anders K.
Tebani, Abdellah
Malmodin, Daniel
Pedersen, Anders
Hellgren, Gunnel
Löfqvist, Chatarina
Hansen-Pupp, Ingrid
Uhlén, Mathias
Hellström, Ann
Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities
title Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities
title_full Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities
title_fullStr Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities
title_full_unstemmed Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities
title_short Longitudinal Serum Metabolomics in Extremely Premature Infants: Relationships With Gestational Age, Nutrition, and Morbidities
title_sort longitudinal serum metabolomics in extremely premature infants: relationships with gestational age, nutrition, and morbidities
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891494/
https://www.ncbi.nlm.nih.gov/pubmed/35250465
http://dx.doi.org/10.3389/fnins.2022.830884
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