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Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease

Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin in plasma correlate significantly with motor dysfuncti...

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Detalles Bibliográficos
Autores principales:	Sepúlveda, Denisse, Cisternas-Olmedo, Marisol, Arcos, Javiera, Nassif, Melissa, Vidal, René L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891570/ https://www.ncbi.nlm.nih.gov/pubmed/35250476 http://dx.doi.org/10.3389/fnmol.2022.805087

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