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The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling

Mitophagy is an intracellular mechanism to maintain mitochondrial health by removing dysfunctional mitochondria. The E3 ligase Parkin ubiquitinates the membrane proteins on targeted mitochondria to initiate mitophagy, whereas USP30 antagonizes Parkin-dependent mitophagy by removing ubiquitin from Pa...

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Detalles Bibliográficos
Autores principales:	Zhang, Ruohan, Ozgen, Serra, Luo, Hongke, Krigman, Judith, Zhao, Yutong, Xin, Gang, Sun, Nuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891576/ https://www.ncbi.nlm.nih.gov/pubmed/35250566 http://dx.doi.org/10.3389/fphar.2022.816551

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