Activation of immune cell proteasomes in peripheral blood of smokers and COPD patients: implications for therapy

BACKGROUND: Immune cells contain a specialised type of proteasome, i.e. the immunoproteasome, which is required for intracellular protein degradation. Immunoproteasomes are key regulators of immune cell differentiation, inflammatory activation and autoimmunity. Immunoproteasome function in periphera...

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Detalles Bibliográficos
Autores principales: Kammerl, Ilona E., Hardy, Sophie, Flexeder, Claudia, Urmann, Andrea, Peierl, Julia, Wang, Yuqin, Vosyka, Oliver, Frankenberger, Marion, Milger, Katrin, Behr, Jürgen, Koch, Andrea, Merl-Pham, Juliane, Hauck, Stefanie M., Pilette, Charles, Schulz, Holger, Meiners, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891681/
https://www.ncbi.nlm.nih.gov/pubmed/34561290
http://dx.doi.org/10.1183/13993003.01798-2021

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