A Review of Targeted Therapies for Monogenic Epilepsy Syndromes

Genetic sequencing technologies have led to an increase in the identification and characterization of monogenic epilepsy syndromes. This increase has, in turn, generated strong interest in developing “precision therapies” based on the unique molecular genetics of a given monogenic epilepsy syndrome....

Descripción completa

Detalles Bibliográficos
Autores principales: Zimmern, Vincent, Minassian, Berge, Korff, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891748/
https://www.ncbi.nlm.nih.gov/pubmed/35250833
http://dx.doi.org/10.3389/fneur.2022.829116
_version_ 1784661965383139328
author Zimmern, Vincent
Minassian, Berge
Korff, Christian
author_facet Zimmern, Vincent
Minassian, Berge
Korff, Christian
author_sort Zimmern, Vincent
collection PubMed
description Genetic sequencing technologies have led to an increase in the identification and characterization of monogenic epilepsy syndromes. This increase has, in turn, generated strong interest in developing “precision therapies” based on the unique molecular genetics of a given monogenic epilepsy syndrome. These therapies include diets, vitamins, cell-signaling regulators, ion channel modulators, repurposed medications, molecular chaperones, and gene therapies. In this review, we evaluate these therapies from the perspective of their clinical validity and discuss the future of these therapies for individual syndromes.
format Online
Article
Text
id pubmed-8891748
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88917482022-03-04 A Review of Targeted Therapies for Monogenic Epilepsy Syndromes Zimmern, Vincent Minassian, Berge Korff, Christian Front Neurol Neurology Genetic sequencing technologies have led to an increase in the identification and characterization of monogenic epilepsy syndromes. This increase has, in turn, generated strong interest in developing “precision therapies” based on the unique molecular genetics of a given monogenic epilepsy syndrome. These therapies include diets, vitamins, cell-signaling regulators, ion channel modulators, repurposed medications, molecular chaperones, and gene therapies. In this review, we evaluate these therapies from the perspective of their clinical validity and discuss the future of these therapies for individual syndromes. Frontiers Media S.A. 2022-02-17 /pmc/articles/PMC8891748/ /pubmed/35250833 http://dx.doi.org/10.3389/fneur.2022.829116 Text en Copyright © 2022 Zimmern, Minassian and Korff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zimmern, Vincent
Minassian, Berge
Korff, Christian
A Review of Targeted Therapies for Monogenic Epilepsy Syndromes
title A Review of Targeted Therapies for Monogenic Epilepsy Syndromes
title_full A Review of Targeted Therapies for Monogenic Epilepsy Syndromes
title_fullStr A Review of Targeted Therapies for Monogenic Epilepsy Syndromes
title_full_unstemmed A Review of Targeted Therapies for Monogenic Epilepsy Syndromes
title_short A Review of Targeted Therapies for Monogenic Epilepsy Syndromes
title_sort review of targeted therapies for monogenic epilepsy syndromes
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891748/
https://www.ncbi.nlm.nih.gov/pubmed/35250833
http://dx.doi.org/10.3389/fneur.2022.829116
work_keys_str_mv AT zimmernvincent areviewoftargetedtherapiesformonogenicepilepsysyndromes
AT minassianberge areviewoftargetedtherapiesformonogenicepilepsysyndromes
AT korffchristian areviewoftargetedtherapiesformonogenicepilepsysyndromes
AT zimmernvincent reviewoftargetedtherapiesformonogenicepilepsysyndromes
AT minassianberge reviewoftargetedtherapiesformonogenicepilepsysyndromes
AT korffchristian reviewoftargetedtherapiesformonogenicepilepsysyndromes

Ejemplares similares