miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review

Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports...

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Detalles Bibliográficos
Autores principales: Di Martino, Maria Teresa, Arbitrio, Mariamena, Caracciolo, Daniele, Cordua, Alessia, Cuomo, Onofrio, Grillone, Katia, Riillo, Caterina, Caridà, Giulio, Scionti, Francesca, Labanca, Caterina, Romeo, Caterina, Siciliano, Maria Anna, D'Apolito, Maria, Napoli, Cristina, Montesano, Martina, Farenza, Valentina, Uppolo, Valentina, Tafuni, Michele, Falcone, Federica, D'Aquino, Giuseppe, Calandruccio, Natale Daniele, Luciano, Francesco, Pensabene, Licia, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891816/
https://www.ncbi.nlm.nih.gov/pubmed/35282417
http://dx.doi.org/10.1016/j.omtn.2022.02.005
Descripción
Sumario:Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.

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