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miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891816/ https://www.ncbi.nlm.nih.gov/pubmed/35282417 http://dx.doi.org/10.1016/j.omtn.2022.02.005 |
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| author | Di Martino, Maria Teresa Arbitrio, Mariamena Caracciolo, Daniele Cordua, Alessia Cuomo, Onofrio Grillone, Katia Riillo, Caterina Caridà, Giulio Scionti, Francesca Labanca, Caterina Romeo, Caterina Siciliano, Maria Anna D'Apolito, Maria Napoli, Cristina Montesano, Martina Farenza, Valentina Uppolo, Valentina Tafuni, Michele Falcone, Federica D'Aquino, Giuseppe Calandruccio, Natale Daniele Luciano, Francesco Pensabene, Licia Tagliaferri, Pierosandro Tassone, Pierfrancesco |
| author_facet | Di Martino, Maria Teresa Arbitrio, Mariamena Caracciolo, Daniele Cordua, Alessia Cuomo, Onofrio Grillone, Katia Riillo, Caterina Caridà, Giulio Scionti, Francesca Labanca, Caterina Romeo, Caterina Siciliano, Maria Anna D'Apolito, Maria Napoli, Cristina Montesano, Martina Farenza, Valentina Uppolo, Valentina Tafuni, Michele Falcone, Federica D'Aquino, Giuseppe Calandruccio, Natale Daniele Luciano, Francesco Pensabene, Licia Tagliaferri, Pierosandro Tassone, Pierfrancesco |
| author_sort | Di Martino, Maria Teresa |
| collection | PubMed |
| description | Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view. |
| format | Online Article Text |
| id | pubmed-8891816 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Society of Gene & Cell Therapy |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-88918162022-03-11 miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review Di Martino, Maria Teresa Arbitrio, Mariamena Caracciolo, Daniele Cordua, Alessia Cuomo, Onofrio Grillone, Katia Riillo, Caterina Caridà, Giulio Scionti, Francesca Labanca, Caterina Romeo, Caterina Siciliano, Maria Anna D'Apolito, Maria Napoli, Cristina Montesano, Martina Farenza, Valentina Uppolo, Valentina Tafuni, Michele Falcone, Federica D'Aquino, Giuseppe Calandruccio, Natale Daniele Luciano, Francesco Pensabene, Licia Tagliaferri, Pierosandro Tassone, Pierfrancesco Mol Ther Nucleic Acids Review Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view. American Society of Gene & Cell Therapy 2022-02-11 /pmc/articles/PMC8891816/ /pubmed/35282417 http://dx.doi.org/10.1016/j.omtn.2022.02.005 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Review Di Martino, Maria Teresa Arbitrio, Mariamena Caracciolo, Daniele Cordua, Alessia Cuomo, Onofrio Grillone, Katia Riillo, Caterina Caridà, Giulio Scionti, Francesca Labanca, Caterina Romeo, Caterina Siciliano, Maria Anna D'Apolito, Maria Napoli, Cristina Montesano, Martina Farenza, Valentina Uppolo, Valentina Tafuni, Michele Falcone, Federica D'Aquino, Giuseppe Calandruccio, Natale Daniele Luciano, Francesco Pensabene, Licia Tagliaferri, Pierosandro Tassone, Pierfrancesco miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review |
| title | miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review |
| title_full | miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review |
| title_fullStr | miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review |
| title_full_unstemmed | miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review |
| title_short | miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review |
| title_sort | mir-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: a systematic review |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891816/ https://www.ncbi.nlm.nih.gov/pubmed/35282417 http://dx.doi.org/10.1016/j.omtn.2022.02.005 |
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