Cargando…

Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours

CASE SUMMARY: An 11-year-old female domestic shorthair cat was presented with cutaneous mast cell tumours (MCTs) localised at the right temporal region, the left buccal region and on the third digit of the right thoracic limb. Staging was negative and locoregional lymph nodes appeared normal, based...

Descripción completa

Detalles Bibliográficos
Autores principales: Arz, Raphael, Seehusen, Frauke, Meier, Valeria S, Nolff, Mirja C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891856/
https://www.ncbi.nlm.nih.gov/pubmed/35251677
http://dx.doi.org/10.1177/20551169221074961
_version_ 1784662001168941056
author Arz, Raphael
Seehusen, Frauke
Meier, Valeria S
Nolff, Mirja C
author_facet Arz, Raphael
Seehusen, Frauke
Meier, Valeria S
Nolff, Mirja C
author_sort Arz, Raphael
collection PubMed
description CASE SUMMARY: An 11-year-old female domestic shorthair cat was presented with cutaneous mast cell tumours (MCTs) localised at the right temporal region, the left buccal region and on the third digit of the right thoracic limb. Staging was negative and locoregional lymph nodes appeared normal, based on clinical findings. During surgery, real-time indocyanine green (ICG)-based lymphography was performed to detect the cutaneous draining pattern of all the primary MCTs. ICG was injected intracutaneously in four quadrants around each tumour, and a clear lymphogram was visible shortly after injection. Using near-infrared lymphography (NIR-L) for guidance, all lymphadenectomies were performed in 12 mins or less, with a maximal incision length of 3.5 cm. The smallest resected node was 0.9 cm in diameter. All MCTs were classified as low-grade cutaneous MCT. All four ICG-positive lymph nodes were considered premetastatic or metastatic. The only ICG-negative resected node was also negative for tumour cells. No complications related to NIR-L were recorded. RELEVANCE AND NOVEL INFORMATION: This is the first description of NIR-L in a cat with MCT. Application was straightforward and ICG enrichment only occurred in the metastatic nodes, suggesting correct identification of lymphatic draining patterns. Of note, as previously described in dogs, we did detect nodal metastasis, despite low-grade primary tumours. The clinical relevance should be evaluated in future studies.
format Online
Article
Text
id pubmed-8891856
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-88918562022-03-04 Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours Arz, Raphael Seehusen, Frauke Meier, Valeria S Nolff, Mirja C JFMS Open Rep Case Report CASE SUMMARY: An 11-year-old female domestic shorthair cat was presented with cutaneous mast cell tumours (MCTs) localised at the right temporal region, the left buccal region and on the third digit of the right thoracic limb. Staging was negative and locoregional lymph nodes appeared normal, based on clinical findings. During surgery, real-time indocyanine green (ICG)-based lymphography was performed to detect the cutaneous draining pattern of all the primary MCTs. ICG was injected intracutaneously in four quadrants around each tumour, and a clear lymphogram was visible shortly after injection. Using near-infrared lymphography (NIR-L) for guidance, all lymphadenectomies were performed in 12 mins or less, with a maximal incision length of 3.5 cm. The smallest resected node was 0.9 cm in diameter. All MCTs were classified as low-grade cutaneous MCT. All four ICG-positive lymph nodes were considered premetastatic or metastatic. The only ICG-negative resected node was also negative for tumour cells. No complications related to NIR-L were recorded. RELEVANCE AND NOVEL INFORMATION: This is the first description of NIR-L in a cat with MCT. Application was straightforward and ICG enrichment only occurred in the metastatic nodes, suggesting correct identification of lymphatic draining patterns. Of note, as previously described in dogs, we did detect nodal metastasis, despite low-grade primary tumours. The clinical relevance should be evaluated in future studies. SAGE Publications 2022-02-27 /pmc/articles/PMC8891856/ /pubmed/35251677 http://dx.doi.org/10.1177/20551169221074961 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Arz, Raphael
Seehusen, Frauke
Meier, Valeria S
Nolff, Mirja C
Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours
title Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours
title_full Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours
title_fullStr Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours
title_full_unstemmed Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours
title_short Indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours
title_sort indocyanine-based near-infrared lymphography for real-time detection of lymphatics in a cat with multiple mast cell tumours
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891856/
https://www.ncbi.nlm.nih.gov/pubmed/35251677
http://dx.doi.org/10.1177/20551169221074961
work_keys_str_mv AT arzraphael indocyaninebasednearinfraredlymphographyforrealtimedetectionoflymphaticsinacatwithmultiplemastcelltumours
AT seehusenfrauke indocyaninebasednearinfraredlymphographyforrealtimedetectionoflymphaticsinacatwithmultiplemastcelltumours
AT meiervalerias indocyaninebasednearinfraredlymphographyforrealtimedetectionoflymphaticsinacatwithmultiplemastcelltumours
AT nolffmirjac indocyaninebasednearinfraredlymphographyforrealtimedetectionoflymphaticsinacatwithmultiplemastcelltumours