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Molecular imaging of tumor-associated macrophages in cancer immunotherapy

Tumor-associated macrophages (TAMs), the most abundant inflammatory cell group in the tumor microenvironment, play an essential role in tumor immune regulation. The infiltration degree of TAMs in the tumor microenvironment is closely related to tumor growth and metastasis, and TAMs have become a pro...

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Autores principales: Li, Xiaoying, Wang, Ruike, Zhang, Yangnan, Han, Shuangze, Gan, Yu, Liang, Qi, Ma, Xiaoqian, Rong, Pengfei, Wang, Wei, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891912/
https://www.ncbi.nlm.nih.gov/pubmed/35251314
http://dx.doi.org/10.1177/17588359221076194
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author Li, Xiaoying
Wang, Ruike
Zhang, Yangnan
Han, Shuangze
Gan, Yu
Liang, Qi
Ma, Xiaoqian
Rong, Pengfei
Wang, Wei
Li, Wei
author_facet Li, Xiaoying
Wang, Ruike
Zhang, Yangnan
Han, Shuangze
Gan, Yu
Liang, Qi
Ma, Xiaoqian
Rong, Pengfei
Wang, Wei
Li, Wei
author_sort Li, Xiaoying
collection PubMed
description Tumor-associated macrophages (TAMs), the most abundant inflammatory cell group in the tumor microenvironment, play an essential role in tumor immune regulation. The infiltration degree of TAMs in the tumor microenvironment is closely related to tumor growth and metastasis, and TAMs have become a promising target in tumor immunotherapy. Molecular imaging is a new interdisciplinary subject that combines medical imaging technology with molecular biology, nuclear medicine, radiation medicine, and computer science. The latest progress in molecular imaging allows the biological processes of cells to be visualized in vivo, which makes it possible to better understand the density and distribution of macrophages in the tumor microenvironment. This review mainly discusses the application of targeting TAM in tumor immunotherapy and the imaging characteristics and progress of targeting TAM molecular probes using various imaging techniques.
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spelling pubmed-88919122022-03-04 Molecular imaging of tumor-associated macrophages in cancer immunotherapy Li, Xiaoying Wang, Ruike Zhang, Yangnan Han, Shuangze Gan, Yu Liang, Qi Ma, Xiaoqian Rong, Pengfei Wang, Wei Li, Wei Ther Adv Med Oncol Review Tumor-associated macrophages (TAMs), the most abundant inflammatory cell group in the tumor microenvironment, play an essential role in tumor immune regulation. The infiltration degree of TAMs in the tumor microenvironment is closely related to tumor growth and metastasis, and TAMs have become a promising target in tumor immunotherapy. Molecular imaging is a new interdisciplinary subject that combines medical imaging technology with molecular biology, nuclear medicine, radiation medicine, and computer science. The latest progress in molecular imaging allows the biological processes of cells to be visualized in vivo, which makes it possible to better understand the density and distribution of macrophages in the tumor microenvironment. This review mainly discusses the application of targeting TAM in tumor immunotherapy and the imaging characteristics and progress of targeting TAM molecular probes using various imaging techniques. SAGE Publications 2022-02-26 /pmc/articles/PMC8891912/ /pubmed/35251314 http://dx.doi.org/10.1177/17588359221076194 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Li, Xiaoying
Wang, Ruike
Zhang, Yangnan
Han, Shuangze
Gan, Yu
Liang, Qi
Ma, Xiaoqian
Rong, Pengfei
Wang, Wei
Li, Wei
Molecular imaging of tumor-associated macrophages in cancer immunotherapy
title Molecular imaging of tumor-associated macrophages in cancer immunotherapy
title_full Molecular imaging of tumor-associated macrophages in cancer immunotherapy
title_fullStr Molecular imaging of tumor-associated macrophages in cancer immunotherapy
title_full_unstemmed Molecular imaging of tumor-associated macrophages in cancer immunotherapy
title_short Molecular imaging of tumor-associated macrophages in cancer immunotherapy
title_sort molecular imaging of tumor-associated macrophages in cancer immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891912/
https://www.ncbi.nlm.nih.gov/pubmed/35251314
http://dx.doi.org/10.1177/17588359221076194
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