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Sebocytes contribute to melasma onset
Melasma is a hyperpigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to the onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891974/ https://www.ncbi.nlm.nih.gov/pubmed/35252805 http://dx.doi.org/10.1016/j.isci.2022.103871 |
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author | Flori, Enrica Mastrofrancesco, Arianna Mosca, Sarah Ottaviani, Monica Briganti, Stefania Cardinali, Giorgia Filoni, Angela Cameli, Norma Zaccarini, Marco Zouboulis, Christos C. Picardo, Mauro |
author_facet | Flori, Enrica Mastrofrancesco, Arianna Mosca, Sarah Ottaviani, Monica Briganti, Stefania Cardinali, Giorgia Filoni, Angela Cameli, Norma Zaccarini, Marco Zouboulis, Christos C. Picardo, Mauro |
author_sort | Flori, Enrica |
collection | PubMed |
description | Melasma is a hyperpigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to the onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet (UVA) radiation was evaluated. UVA up-modulated the long-lasting production of α-MSH, EDN1, b-FGF, SCF, inflammatory cytokines and mediators. Irradiated SZ95 sebocyte conditioned media increased pigmentation in melanocytes and the expression of senescence markers, pro-inflammatory cytokines, and growth factors regulating melanogenesis in fibroblasts cultures. Cocultures experiments with skin explants confirmed the role of sebocytes on melanogenesis promotion. The analysis on sebum collected from melasma patients demonstrated that in vivo sebocytes from lesional areas express the UVA-activated pathways markers observed in vitro. Our results indicate sebocytes as one of the actors in melasma pathogenesis, inducing prolonged skin cell stimulation, contributing to localized dermal aging and hyperpigmentation. |
format | Online Article Text |
id | pubmed-8891974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88919742022-03-04 Sebocytes contribute to melasma onset Flori, Enrica Mastrofrancesco, Arianna Mosca, Sarah Ottaviani, Monica Briganti, Stefania Cardinali, Giorgia Filoni, Angela Cameli, Norma Zaccarini, Marco Zouboulis, Christos C. Picardo, Mauro iScience Article Melasma is a hyperpigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to the onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet (UVA) radiation was evaluated. UVA up-modulated the long-lasting production of α-MSH, EDN1, b-FGF, SCF, inflammatory cytokines and mediators. Irradiated SZ95 sebocyte conditioned media increased pigmentation in melanocytes and the expression of senescence markers, pro-inflammatory cytokines, and growth factors regulating melanogenesis in fibroblasts cultures. Cocultures experiments with skin explants confirmed the role of sebocytes on melanogenesis promotion. The analysis on sebum collected from melasma patients demonstrated that in vivo sebocytes from lesional areas express the UVA-activated pathways markers observed in vitro. Our results indicate sebocytes as one of the actors in melasma pathogenesis, inducing prolonged skin cell stimulation, contributing to localized dermal aging and hyperpigmentation. Elsevier 2022-02-04 /pmc/articles/PMC8891974/ /pubmed/35252805 http://dx.doi.org/10.1016/j.isci.2022.103871 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Flori, Enrica Mastrofrancesco, Arianna Mosca, Sarah Ottaviani, Monica Briganti, Stefania Cardinali, Giorgia Filoni, Angela Cameli, Norma Zaccarini, Marco Zouboulis, Christos C. Picardo, Mauro Sebocytes contribute to melasma onset |
title | Sebocytes contribute to melasma onset |
title_full | Sebocytes contribute to melasma onset |
title_fullStr | Sebocytes contribute to melasma onset |
title_full_unstemmed | Sebocytes contribute to melasma onset |
title_short | Sebocytes contribute to melasma onset |
title_sort | sebocytes contribute to melasma onset |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891974/ https://www.ncbi.nlm.nih.gov/pubmed/35252805 http://dx.doi.org/10.1016/j.isci.2022.103871 |
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