Cargando…
A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity
Pure red cell aplasia (PRCA), Good's syndrome (GS), and thymoma-associated multiorgan autoimmunity (TAMA) are associated with thymoma. Herein, we describe the case of a 56-year-old woman with PRCA, GS, and TAMA simultaneously. She was treated with cyclosporine, immunoglobulin supplementation, a...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892002/ https://www.ncbi.nlm.nih.gov/pubmed/35251929 http://dx.doi.org/10.1016/j.rmcr.2022.101619 |
_version_ | 1784662042021462016 |
---|---|
author | Nakagawa, Yuta Matsumoto, Kinnosuke Yamamoto, Makoto Hirata, Haruhiko Shiroyama, Takayuki Miyake, Kotaro Yamamoto, Yuji Kuge, Tomoki Yoneda, Midori Naito, Yujiro Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi |
author_facet | Nakagawa, Yuta Matsumoto, Kinnosuke Yamamoto, Makoto Hirata, Haruhiko Shiroyama, Takayuki Miyake, Kotaro Yamamoto, Yuji Kuge, Tomoki Yoneda, Midori Naito, Yujiro Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi |
author_sort | Nakagawa, Yuta |
collection | PubMed |
description | Pure red cell aplasia (PRCA), Good's syndrome (GS), and thymoma-associated multiorgan autoimmunity (TAMA) are associated with thymoma. Herein, we describe the case of a 56-year-old woman with PRCA, GS, and TAMA simultaneously. She was treated with cyclosporine, immunoglobulin supplementation, and prednisolone; however, she died of uncontrolled sepsis due to extreme immunosuppression. The combination of these three diseases is likely to lead to fatal infections, and to avoid such infections, it may be necessary to reduce or discontinue immunosuppressants and steroids as soon as possible if the diseases are controlled, as well as regular immunoglobulin supplementation. |
format | Online Article Text |
id | pubmed-8892002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88920022022-03-04 A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity Nakagawa, Yuta Matsumoto, Kinnosuke Yamamoto, Makoto Hirata, Haruhiko Shiroyama, Takayuki Miyake, Kotaro Yamamoto, Yuji Kuge, Tomoki Yoneda, Midori Naito, Yujiro Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi Respir Med Case Rep Case Report Pure red cell aplasia (PRCA), Good's syndrome (GS), and thymoma-associated multiorgan autoimmunity (TAMA) are associated with thymoma. Herein, we describe the case of a 56-year-old woman with PRCA, GS, and TAMA simultaneously. She was treated with cyclosporine, immunoglobulin supplementation, and prednisolone; however, she died of uncontrolled sepsis due to extreme immunosuppression. The combination of these three diseases is likely to lead to fatal infections, and to avoid such infections, it may be necessary to reduce or discontinue immunosuppressants and steroids as soon as possible if the diseases are controlled, as well as regular immunoglobulin supplementation. Elsevier 2022-02-23 /pmc/articles/PMC8892002/ /pubmed/35251929 http://dx.doi.org/10.1016/j.rmcr.2022.101619 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Nakagawa, Yuta Matsumoto, Kinnosuke Yamamoto, Makoto Hirata, Haruhiko Shiroyama, Takayuki Miyake, Kotaro Yamamoto, Yuji Kuge, Tomoki Yoneda, Midori Naito, Yujiro Suga, Yasuhiko Fukushima, Kiyoharu Koyama, Shohei Iwahori, Kota Nagatomo, Izumi Takeda, Yoshito Kumanogoh, Atsushi A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity |
title | A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity |
title_full | A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity |
title_fullStr | A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity |
title_full_unstemmed | A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity |
title_short | A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity |
title_sort | case of synchronous triple autoimmune disorders secondary to thymoma: pure red cell aplasia, good's syndrome, and thymoma-associated multi-organ autoimmunity |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892002/ https://www.ncbi.nlm.nih.gov/pubmed/35251929 http://dx.doi.org/10.1016/j.rmcr.2022.101619 |
work_keys_str_mv | AT nakagawayuta acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT matsumotokinnosuke acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT yamamotomakoto acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT hirataharuhiko acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT shiroyamatakayuki acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT miyakekotaro acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT yamamotoyuji acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT kugetomoki acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT yonedamidori acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT naitoyujiro acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT sugayasuhiko acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT fukushimakiyoharu acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT koyamashohei acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT iwahorikota acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT nagatomoizumi acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT takedayoshito acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT kumanogohatsushi acaseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT nakagawayuta caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT matsumotokinnosuke caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT yamamotomakoto caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT hirataharuhiko caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT shiroyamatakayuki caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT miyakekotaro caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT yamamotoyuji caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT kugetomoki caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT yonedamidori caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT naitoyujiro caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT sugayasuhiko caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT fukushimakiyoharu caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT koyamashohei caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT iwahorikota caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT nagatomoizumi caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT takedayoshito caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity AT kumanogohatsushi caseofsynchronoustripleautoimmunedisorderssecondarytothymomapureredcellaplasiagoodssyndromeandthymomaassociatedmultiorganautoimmunity |