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Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development

Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole(+/P286R);Trp53(+/–) mice showed accelerated cancer mortality compared to Pol...

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Detalles Bibliográficos
Autores principales:	Park, Vivian S, Sun, Meijuan J S, Frey, Wesley D, Williams, Leonard G, Hodel, Karl P, Strauss, Juliet D, Wellens, Sydney J, Jackson, James G, Pursell, Zachary F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892059/ https://www.ncbi.nlm.nih.gov/pubmed/35252866 http://dx.doi.org/10.1093/narcan/zcac004

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