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Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells

Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic changes including vulnerability to inhibitors of protein synthesis and of the p53...

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Detalles Bibliográficos
Autores principales:	Florian, Andrea C, Woodley, Chase M, Wang, Jing, Grieb, Brian C, Slota, Macey J, Guerrazzi, Kiana, Hsu, Chih-Yuan, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Fesik, Stephen W, Howard, Gregory C, Liu, Qi, Weissmiller, April M, Tansey, William P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892060/ https://www.ncbi.nlm.nih.gov/pubmed/35252869 http://dx.doi.org/10.1093/narcan/zcac007

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