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Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme

OBJECTIVE: There is evidence that colorectal cancer screening using faecal haemoglobin is less effective in women than men. The faecal haemoglobin concentrations were therefore examined in women and men with screen-detected colorectal cancer. SETTING: Scottish Bowel Screening Programme, following th...

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Autores principales: Clark, Gavin RC, Digby, Jayne, Fraser, Callum G, Strachan, Judith A, Steele, Robert JC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892068/
https://www.ncbi.nlm.nih.gov/pubmed/34806935
http://dx.doi.org/10.1177/09691413211056970
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author Clark, Gavin RC
Digby, Jayne
Fraser, Callum G
Strachan, Judith A
Steele, Robert JC
author_facet Clark, Gavin RC
Digby, Jayne
Fraser, Callum G
Strachan, Judith A
Steele, Robert JC
author_sort Clark, Gavin RC
collection PubMed
description OBJECTIVE: There is evidence that colorectal cancer screening using faecal haemoglobin is less effective in women than men. The faecal haemoglobin concentrations were therefore examined in women and men with screen-detected colorectal cancer. SETTING: Scottish Bowel Screening Programme, following the introduction of a faecal immunochemical test from November 2017, to March 2020. METHODS: Data were collated on faecal haemoglobin concentrations, pathological stage and anatomical site of the main lesion in participants who had colorectal cancer detected. The data in women and men were compared. RESULTS: For the faecal haemoglobin concentrations studied (>80 µg Hb/g faeces), the distributions indicated lower concentrations in women. Marked differences were found between women and men diagnosed with colorectal cancer. The median faecal haemoglobin concentration for women (n = 720) was 408 µg Hb/g faeces compared to 473 µg Hb/g faeces for men (n = 959) (p = 0.004) and 50.6% of the results were >400 µg Hb/g faeces in women; in men, this was 57.8%. The difference in faecal haemoglobin concentrations in women and men became less statistically significant as stage advanced from stages I–IV. For right-sided, left-sided and rectal colorectal cancer, a similar gender difference persisted in all sites. Differences in faecal haemoglobin between the genders were significant for left-sided cancers and stage I and approached significance for rectal cancers and stage II, but all sites and stages showed lower median faecal haemoglobin concentrations for women. CONCLUSIONS: To minimise gender inequalities, faecal immunochemical test-based colorectal cancer screening programmes should evaluate a strategy of using different faecal haemoglobin concentration thresholds in women and men.
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spelling pubmed-88920682022-03-04 Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme Clark, Gavin RC Digby, Jayne Fraser, Callum G Strachan, Judith A Steele, Robert JC J Med Screen Original Articles OBJECTIVE: There is evidence that colorectal cancer screening using faecal haemoglobin is less effective in women than men. The faecal haemoglobin concentrations were therefore examined in women and men with screen-detected colorectal cancer. SETTING: Scottish Bowel Screening Programme, following the introduction of a faecal immunochemical test from November 2017, to March 2020. METHODS: Data were collated on faecal haemoglobin concentrations, pathological stage and anatomical site of the main lesion in participants who had colorectal cancer detected. The data in women and men were compared. RESULTS: For the faecal haemoglobin concentrations studied (>80 µg Hb/g faeces), the distributions indicated lower concentrations in women. Marked differences were found between women and men diagnosed with colorectal cancer. The median faecal haemoglobin concentration for women (n = 720) was 408 µg Hb/g faeces compared to 473 µg Hb/g faeces for men (n = 959) (p = 0.004) and 50.6% of the results were >400 µg Hb/g faeces in women; in men, this was 57.8%. The difference in faecal haemoglobin concentrations in women and men became less statistically significant as stage advanced from stages I–IV. For right-sided, left-sided and rectal colorectal cancer, a similar gender difference persisted in all sites. Differences in faecal haemoglobin between the genders were significant for left-sided cancers and stage I and approached significance for rectal cancers and stage II, but all sites and stages showed lower median faecal haemoglobin concentrations for women. CONCLUSIONS: To minimise gender inequalities, faecal immunochemical test-based colorectal cancer screening programmes should evaluate a strategy of using different faecal haemoglobin concentration thresholds in women and men. SAGE Publications 2021-11-22 2022-03 /pmc/articles/PMC8892068/ /pubmed/34806935 http://dx.doi.org/10.1177/09691413211056970 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Clark, Gavin RC
Digby, Jayne
Fraser, Callum G
Strachan, Judith A
Steele, Robert JC
Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme
title Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme
title_full Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme
title_fullStr Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme
title_full_unstemmed Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme
title_short Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme
title_sort faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892068/
https://www.ncbi.nlm.nih.gov/pubmed/34806935
http://dx.doi.org/10.1177/09691413211056970
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