Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4

The secreted form of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), which catalyzes a key reaction in intracellular NAD biosynthesis, acts as a damage-associated molecular pattern triggering Toll-like receptor 4 (TLR4)-mediated inflammatory responses. However, the precise mechanism of in...

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Detalles Bibliográficos
Autores principales: Gasparrini, Massimiliano, Mazzola, Francesca, Cuccioloni, Massimiliano, Sorci, Leonardo, Audrito, Valentina, Zamporlini, Federica, Fortunato, Carlo, Amici, Adolfo, Cianci, Michele, Deaglio, Silvia, Angeletti, Mauro, Raffaelli, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892085/
https://www.ncbi.nlm.nih.gov/pubmed/35120922
http://dx.doi.org/10.1016/j.jbc.2022.101669

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