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A nanoconcrete welding strategy for constructing high-performance wound dressing

Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances, and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many cases. In this work, we propose a new concept of nanoconcrete welding...

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Detalles Bibliográficos
Autores principales: Wang, Yingshuai, Zhu, Yanxia, Zhao, Penghe, Wei, Bin, Fan, Mingjian, Chen, Danyang, Jin, Zhaokui, He, Qianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892149/
https://www.ncbi.nlm.nih.gov/pubmed/35310347
http://dx.doi.org/10.1016/j.bioactmat.2021.12.014
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author Wang, Yingshuai
Zhu, Yanxia
Zhao, Penghe
Wei, Bin
Fan, Mingjian
Chen, Danyang
Jin, Zhaokui
He, Qianjun
author_facet Wang, Yingshuai
Zhu, Yanxia
Zhao, Penghe
Wei, Bin
Fan, Mingjian
Chen, Danyang
Jin, Zhaokui
He, Qianjun
author_sort Wang, Yingshuai
collection PubMed
description Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances, and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many cases. In this work, we propose a new concept of nanoconcrete welding polymer chains, where mesoporous CaCO(3) (mCaCO(3)) nanoconcretes which are composed of amorphous and nanocrystalline phases are developed to powerfully weld polymer chains through siphoning-induced occlusion, hydration-driven crystallization and dehydration-driven compression of nanoconcretes. The mCaCO(3) nanoconcrete welding technology is verified to be able to remarkably augment strength, toughness and anti-fatigue performances of a model polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based porous membrane. Mechanistically, we have revealed polymer-occluded nanocrystal structure and welding-derived microstress which is much stronger than interfacial Van der Waals force, thus efficiently preventing the generation of microcracks and repairing initial microcracks by microcracks-induced hydration, crystallization and polymer welding of mCaCO(3) nanoconcretes. Constructed porous membrane is used as wound dressing, exhibiting a special nanoplates-constructed surface topography as well as a porous structure with plentiful oriented, aligned and opened pore channels, improved hydrophilicity, water vapor permeability, anti-bacterial and cell adherence, in support of wound healing and skin structural/functional repairing. The proposed nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.
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spelling pubmed-88921492022-03-17 A nanoconcrete welding strategy for constructing high-performance wound dressing Wang, Yingshuai Zhu, Yanxia Zhao, Penghe Wei, Bin Fan, Mingjian Chen, Danyang Jin, Zhaokui He, Qianjun Bioact Mater Article Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances, and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many cases. In this work, we propose a new concept of nanoconcrete welding polymer chains, where mesoporous CaCO(3) (mCaCO(3)) nanoconcretes which are composed of amorphous and nanocrystalline phases are developed to powerfully weld polymer chains through siphoning-induced occlusion, hydration-driven crystallization and dehydration-driven compression of nanoconcretes. The mCaCO(3) nanoconcrete welding technology is verified to be able to remarkably augment strength, toughness and anti-fatigue performances of a model polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based porous membrane. Mechanistically, we have revealed polymer-occluded nanocrystal structure and welding-derived microstress which is much stronger than interfacial Van der Waals force, thus efficiently preventing the generation of microcracks and repairing initial microcracks by microcracks-induced hydration, crystallization and polymer welding of mCaCO(3) nanoconcretes. Constructed porous membrane is used as wound dressing, exhibiting a special nanoplates-constructed surface topography as well as a porous structure with plentiful oriented, aligned and opened pore channels, improved hydrophilicity, water vapor permeability, anti-bacterial and cell adherence, in support of wound healing and skin structural/functional repairing. The proposed nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers. KeAi Publishing 2021-12-18 /pmc/articles/PMC8892149/ /pubmed/35310347 http://dx.doi.org/10.1016/j.bioactmat.2021.12.014 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wang, Yingshuai
Zhu, Yanxia
Zhao, Penghe
Wei, Bin
Fan, Mingjian
Chen, Danyang
Jin, Zhaokui
He, Qianjun
A nanoconcrete welding strategy for constructing high-performance wound dressing
title A nanoconcrete welding strategy for constructing high-performance wound dressing
title_full A nanoconcrete welding strategy for constructing high-performance wound dressing
title_fullStr A nanoconcrete welding strategy for constructing high-performance wound dressing
title_full_unstemmed A nanoconcrete welding strategy for constructing high-performance wound dressing
title_short A nanoconcrete welding strategy for constructing high-performance wound dressing
title_sort nanoconcrete welding strategy for constructing high-performance wound dressing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892149/
https://www.ncbi.nlm.nih.gov/pubmed/35310347
http://dx.doi.org/10.1016/j.bioactmat.2021.12.014
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